WNT1 | OmnibusX

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of WNT1 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
spleen	100%	39.40	240 / 241	0%	0	0 / 0
lung	83%	11.93	479 / 578	5%	0.26	61 / 1155
peripheral blood	77%	19.69	719 / 929	0%	0	0 / 0
brain	67%	58.10	1758 / 2642	5%	0.12	38 / 705
stomach	62%	7.53	221 / 359	3%	0.08	9 / 286
thymus	61%	7.57	399 / 653	3%	0.04	17 / 605
prostate	62%	6.89	152 / 245	0%	0.01	2 / 502
intestine	52%	15.23	502 / 966	2%	0.08	13 / 527
bladder	48%	6.71	10 / 21	1%	0.04	6 / 504
breast	47%	5.30	214 / 459	1%	0.02	14 / 1118
adipose	47%	4.82	565 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	45%	0.79	13 / 29
esophagus	30%	2.63	430 / 1445	7%	0.27	12 / 183
uterus	25%	1.96	43 / 170	7%	0.17	33 / 459
kidney	30%	4.02	27 / 89	2%	0.03	17 / 901
blood vessel	23%	2.44	311 / 1335	0%	0	0 / 0
heart	22%	2.22	190 / 861	0%	0	0 / 0
skin	18%	1.39	328 / 1809	3%	0.08	15 / 472
liver	19%	1.56	44 / 226	2%	0.30	7 / 406
adrenal gland	15%	1.08	39 / 258	2%	0.71	5 / 230
ovary	16%	2.24	28 / 180	1%	0.03	3 / 430
pancreas	13%	0.86	42 / 328	3%	0.04	6 / 178
muscle	5%	0.36	37 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	4%	0.17	2 / 45
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0001658	Biological process	branching involved in ureteric bud morphogenesis
GO_0048146	Biological process	positive regulation of fibroblast proliferation
GO_0021527	Biological process	spinal cord association neuron differentiation
GO_2000059	Biological process	negative regulation of ubiquitin-dependent protein catabolic process
GO_0030512	Biological process	negative regulation of transforming growth factor beta receptor signaling pathway
GO_0051091	Biological process	positive regulation of DNA-binding transcription factor activity
GO_0045444	Biological process	fat cell differentiation
GO_1903377	Biological process	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO_1904948	Biological process	midbrain dopaminergic neuron differentiation
GO_1902035	Biological process	positive regulation of hematopoietic stem cell proliferation
GO_0030901	Biological process	midbrain development
GO_0010592	Biological process	positive regulation of lamellipodium assembly
GO_0045599	Biological process	negative regulation of fat cell differentiation
GO_1990403	Biological process	embryonic brain development
GO_0021536	Biological process	diencephalon development
GO_0031100	Biological process	animal organ regeneration
GO_0061184	Biological process	positive regulation of dermatome development
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0071425	Biological process	hematopoietic stem cell proliferation
GO_0007267	Biological process	cell-cell signaling
GO_0060070	Biological process	canonical Wnt signaling pathway
GO_0021588	Biological process	cerebellum formation
GO_0033077	Biological process	T cell differentiation in thymus
GO_0030182	Biological process	neuron differentiation
GO_0045165	Biological process	cell fate commitment
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0048664	Biological process	neuron fate determination
GO_0033278	Biological process	cell proliferation in midbrain
GO_0071375	Biological process	cellular response to peptide hormone stimulus
GO_0043568	Biological process	positive regulation of insulin-like growth factor receptor signaling pathway
GO_0022004	Biological process	midbrain-hindbrain boundary maturation during brain development
GO_0060061	Biological process	Spemann organizer formation
GO_0000578	Biological process	embryonic axis specification
GO_0042472	Biological process	inner ear morphogenesis
GO_0036520	Biological process	astrocyte-dopaminergic neuron signaling
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0021797	Biological process	forebrain anterior/posterior pattern specification
GO_0016055	Biological process	Wnt signaling pathway
GO_0007520	Biological process	myoblast fusion
GO_0060348	Biological process	bone development
GO_0045747	Biological process	positive regulation of Notch signaling pathway
GO_0021551	Biological process	central nervous system morphogenesis
GO_0070365	Biological process	hepatocyte differentiation
GO_0009611	Biological process	response to wounding
GO_0042770	Biological process	signal transduction in response to DNA damage
GO_0010812	Biological process	negative regulation of cell-substrate adhesion
GO_2000773	Biological process	negative regulation of cellular senescence
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0022408	Biological process	negative regulation of cell-cell adhesion
GO_0005615	Cellular component	extracellular space
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0030666	Cellular component	endocytic vesicle membrane
GO_0005796	Cellular component	Golgi lumen
GO_0070062	Cellular component	extracellular exosome
GO_0009986	Cellular component	cell surface
GO_0005788	Cellular component	endoplasmic reticulum lumen
GO_0005737	Cellular component	cytoplasm
GO_0019904	Molecular function	protein domain specific binding
GO_0048018	Molecular function	receptor ligand activity
GO_0005109	Molecular function	frizzled binding
GO_0016015	Molecular function	morphogen activity
GO_0005125	Molecular function	cytokine activity

Gene name	WNT1
Protein name	Proto-oncogene Wnt-1 (Proto-oncogene Int-1 homolog)
Synonyms	INT1
Description	FUNCTION: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation . In some developmental processes, is also a ligand for the coreceptor RYK, thus triggering Wnt signaling (By similarity). Plays an essential role in the development of the embryonic brain and central nervous system (CNS) (By similarity). Has a role in osteoblast function, bone development and bone homeostasis . .
Accessions	ENST00000293549.4 P04628

WNT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review