MAPKAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030307Biological processpositive regulation of cell growth
GO_0033138Biological processpositive regulation of peptidyl-serine phosphorylation
GO_0007010Biological processcytoskeleton organization
GO_0038203Biological processTORC2 signaling
GO_0046580Biological processnegative regulation of Ras protein signal transduction
GO_0031669Biological processcellular response to nutrient levels
GO_0043066Biological processnegative regulation of apoptotic process
GO_1900407Biological processregulation of cellular response to oxidative stress
GO_0021762Biological processsubstantia nigra development
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0031932Cellular componentTORC2 complex
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005547Molecular functionphosphatidylinositol-3,4,5-trisphosphate binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0019901Molecular functionprotein kinase binding
GO_0031267Molecular functionsmall GTPase binding
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0070300Molecular functionphosphatidic acid binding
GO_0005515Molecular functionprotein binding
GO_0043325Molecular functionphosphatidylinositol-3,4-bisphosphate binding

IV. Literature review

[source]
Gene nameMAPKAP1
Protein nameTarget of rapamycin complex 2 subunit MAPKAP1 (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1)
Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1)
Alternative protein MAPKAP1
MAPK associated protein 1
SynonymsMIP1
SIN1
DescriptionFUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. .

AccessionsB1AMB1
B1AMB2
B1AMA6
ENST00000373503.7 [Q9BPZ7-4]
ENST00000350766.7 [Q9BPZ7-2]
ENST00000420643.5
ENST00000497932.5
ENST00000373498.5 [Q9BPZ7-1]
L8EC63
ENST00000265960.8 [Q9BPZ7-1]
ENST00000373511.6 [Q9BPZ7-3]
Q9BPZ7
ENST00000444226.1
B1AMA5
E9PGB8
H0Y7F8
ENST00000468896.1
H0Y866
ENST00000394063.5 [Q9BPZ7-4]
ENST00000394060.7 [Q9BPZ7-5]
ENST00000433483.1
ENST00000373496.3
ENST00000427078.5