Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 19 studies | 30% ± 11% | |
astrocyte | 14 studies | 33% ± 17% | |
macrophage | 13 studies | 33% ± 15% | |
oligodendrocyte | 12 studies | 33% ± 12% | |
microglial cell | 11 studies | 37% ± 14% | |
oligodendrocyte precursor cell | 11 studies | 35% ± 15% | |
glutamatergic neuron | 10 studies | 42% ± 25% | |
fibroblast | 10 studies | 26% ± 7% | |
adipocyte | 9 studies | 28% ± 8% | |
GABAergic neuron | 8 studies | 41% ± 22% | |
epithelial cell | 8 studies | 31% ± 14% | |
interneuron | 7 studies | 38% ± 22% | |
B cell | 7 studies | 21% ± 6% | |
myeloid cell | 7 studies | 34% ± 14% | |
dendritic cell | 7 studies | 27% ± 8% | |
ciliated cell | 7 studies | 22% ± 7% | |
neuron | 6 studies | 38% ± 18% | |
retina horizontal cell | 6 studies | 25% ± 6% | |
basal cell | 6 studies | 28% ± 13% | |
type I pneumocyte | 6 studies | 26% ± 8% | |
type II pneumocyte | 6 studies | 23% ± 5% | |
non-classical monocyte | 5 studies | 21% ± 6% | |
myofibroblast cell | 5 studies | 23% ± 6% | |
amacrine cell | 5 studies | 18% ± 4% | |
endothelial cell of lymphatic vessel | 5 studies | 30% ± 7% | |
monocyte | 5 studies | 33% ± 10% | |
club cell | 5 studies | 23% ± 7% | |
pericyte | 5 studies | 26% ± 8% | |
smooth muscle cell | 5 studies | 24% ± 3% | |
natural killer cell | 4 studies | 19% ± 4% | |
granule cell | 4 studies | 26% ± 7% | |
retinal bipolar neuron | 4 studies | 16% ± 1% | |
retinal cone cell | 4 studies | 24% ± 5% | |
cardiac muscle cell | 4 studies | 26% ± 1% | |
mast cell | 4 studies | 22% ± 6% | |
lymphocyte | 4 studies | 28% ± 7% | |
retinal rod cell | 4 studies | 24% ± 4% | |
T cell | 4 studies | 21% ± 3% | |
connective tissue cell | 4 studies | 20% ± 3% | |
GABAergic interneuron | 3 studies | 25% ± 5% | |
glial cell | 3 studies | 20% ± 4% | |
mesothelial cell | 3 studies | 24% ± 5% | |
mononuclear phagocyte | 3 studies | 26% ± 7% | |
rod bipolar cell | 3 studies | 19% ± 4% | |
respiratory goblet cell | 3 studies | 20% ± 3% | |
hepatocyte | 3 studies | 42% ± 18% | |
abnormal cell | 3 studies | 29% ± 11% | |
neural progenitor cell | 3 studies | 23% ± 6% | |
leukocyte | 3 studies | 26% ± 9% | |
alveolar macrophage | 3 studies | 48% ± 10% | |
goblet cell | 3 studies | 32% ± 21% | |
transit amplifying cell | 3 studies | 33% ± 21% | |
plasmacytoid dendritic cell | 3 studies | 21% ± 4% |
Name | Number of supported studies | Average coverage | |
---|---|---|---|
brain | 16 studies | 34% ± 19% | |
lung | 6 studies | 24% ± 6% | |
eye | 5 studies | 26% ± 11% | |
heart | 4 studies | 22% ± 4% | |
liver | 4 studies | 28% ± 11% | |
peripheral blood | 3 studies | 20% ± 2% | |
intestine | 3 studies | 20% ± 5% | |
adipose | 3 studies | 27% ± 1% | |
kidney | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 100% | 4302.81 | 459 / 459 | 100% | 39.64 | 1118 / 1118 |
esophagus | 100% | 5408.49 | 1445 / 1445 | 100% | 30.65 | 183 / 183 |
intestine | 100% | 5530.05 | 966 / 966 | 100% | 34.58 | 527 / 527 |
ovary | 100% | 3499.92 | 180 / 180 | 100% | 32.07 | 430 / 430 |
prostate | 100% | 4328.27 | 245 / 245 | 100% | 35.27 | 502 / 502 |
stomach | 100% | 4192.49 | 359 / 359 | 100% | 32.01 | 286 / 286 |
uterus | 100% | 4317.60 | 170 / 170 | 100% | 34.30 | 459 / 459 |
brain | 100% | 4802.41 | 2641 / 2642 | 100% | 42.96 | 705 / 705 |
skin | 100% | 4792.64 | 1808 / 1809 | 100% | 36.45 | 472 / 472 |
thymus | 100% | 4185.91 | 653 / 653 | 100% | 33.84 | 604 / 605 |
pancreas | 100% | 2603.84 | 327 / 328 | 100% | 26.59 | 178 / 178 |
lung | 100% | 3862.30 | 576 / 578 | 100% | 34.65 | 1155 / 1155 |
bladder | 100% | 5805.10 | 21 / 21 | 100% | 30.83 | 502 / 504 |
kidney | 100% | 4373.26 | 89 / 89 | 99% | 26.24 | 895 / 901 |
liver | 99% | 2551.28 | 224 / 226 | 100% | 22.14 | 405 / 406 |
adrenal gland | 100% | 6831.02 | 258 / 258 | 97% | 22.47 | 224 / 230 |
adipose | 100% | 4477.69 | 1204 / 1204 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 41.95 | 29 / 29 |
muscle | 100% | 5835.51 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3406.95 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 39.21 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 23.69 | 1 / 1 |
blood vessel | 100% | 4442.09 | 1334 / 1335 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 99% | 31.72 | 79 / 80 |
heart | 98% | 4589.36 | 841 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 88% | 3463.92 | 817 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0030307 | Biological process | positive regulation of cell growth |
GO_0033138 | Biological process | positive regulation of peptidyl-serine phosphorylation |
GO_0007010 | Biological process | cytoskeleton organization |
GO_0038203 | Biological process | TORC2 signaling |
GO_0046580 | Biological process | negative regulation of Ras protein signal transduction |
GO_0031669 | Biological process | cellular response to nutrient levels |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_1900407 | Biological process | regulation of cellular response to oxidative stress |
GO_0021762 | Biological process | substantia nigra development |
GO_0005886 | Cellular component | plasma membrane |
GO_0031410 | Cellular component | cytoplasmic vesicle |
GO_0031932 | Cellular component | TORC2 complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005794 | Cellular component | Golgi apparatus |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005547 | Molecular function | phosphatidylinositol-3,4,5-trisphosphate binding |
GO_0060090 | Molecular function | molecular adaptor activity |
GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0031267 | Molecular function | small GTPase binding |
GO_0080025 | Molecular function | phosphatidylinositol-3,5-bisphosphate binding |
GO_0070300 | Molecular function | phosphatidic acid binding |
GO_0005515 | Molecular function | protein binding |
GO_0043325 | Molecular function | phosphatidylinositol-3,4-bisphosphate binding |
Gene name | MAPKAP1 |
Protein name | Target of rapamycin complex 2 subunit MAPKAP1 (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) (mSIN1) Alternative protein MAPKAP1 MAPK associated protein 1 |
Synonyms | MIP1 SIN1 |
Description | FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. . |
Accessions | B1AMB1 B1AMB2 B1AMA6 ENST00000373503.7 [Q9BPZ7-4] ENST00000350766.7 [Q9BPZ7-2] ENST00000420643.5 ENST00000497932.5 ENST00000373498.5 [Q9BPZ7-1] L8EC63 ENST00000265960.8 [Q9BPZ7-1] ENST00000373511.6 [Q9BPZ7-3] Q9BPZ7 ENST00000444226.1 B1AMA5 E9PGB8 H0Y7F8 ENST00000468896.1 H0Y866 ENST00000394063.5 [Q9BPZ7-4] ENST00000394060.7 [Q9BPZ7-5] ENST00000433483.1 ENST00000373496.3 ENST00000427078.5 |