CDC73 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045638Biological processnegative regulation of myeloid cell differentiation
GO_0008285Biological processnegative regulation of cell population proliferation
GO_1902808Biological processpositive regulation of cell cycle G1/S phase transition
GO_0048147Biological processnegative regulation of fibroblast proliferation
GO_0001558Biological processregulation of cell growth
GO_0031124Biological processmRNA 3'-end processing
GO_0031442Biological processpositive regulation of mRNA 3'-end processing
GO_0006368Biological processtranscription elongation by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0031648Biological processprotein destabilization
GO_0050680Biological processnegative regulation of epithelial cell proliferation
GO_0032968Biological processpositive regulation of transcription elongation by RNA polymerase II
GO_0001711Biological processendodermal cell fate commitment
GO_0043066Biological processnegative regulation of apoptotic process
GO_0019827Biological processstem cell population maintenance
GO_0071222Biological processcellular response to lipopolysaccharide
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0016055Biological processWnt signaling pathway
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0016593Cellular componentCdc73/Paf1 complex
GO_0005829Cellular componentcytosol
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0000993Molecular functionRNA polymerase II complex binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCDC73
Protein nameCell division cycle 73
Parafibromin (Cell division cycle protein 73 homolog) (Hyperparathyroidism 2 protein)
Cell division cycle 73 Paf1/RNA polymerase II complex component-like protein isoform 2
Cell division cycle 73 Paf1/RNA polymerase II complex component-like protein isoform 1
SynonymsHRPT2
C1orf28
DescriptionFUNCTION: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. .

AccessionsENST00000643006.1
A0A2R8Y640
A0A1B0GUB2
A0A3B3IRP5
Q6P1J9
ENST00000635846.1
A0A0S2Z5N1
A0A2R8YHB3
A0A3B3ISN2
ENST00000648071.1
ENST00000650197.1
A0A0S2Z5M9
ENST00000643784.1
ENST00000367435.5