I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 36% ± 14% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 36% ± 14% |
Insufficient scRNA-seq data for expression of IHH at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 84% | 857.92 | 301 / 359 | 85% | 91.37 | 243 / 286 |
| intestine | 75% | 1171.47 | 722 / 966 | 89% | 93.74 | 471 / 527 |
| prostate | 95% | 245.43 | 232 / 245 | 59% | 13.16 | 298 / 502 |
| liver | 100% | 169.42 | 225 / 226 | 30% | 5.78 | 122 / 406 |
| kidney | 99% | 193.19 | 88 / 89 | 18% | 2.79 | 160 / 901 |
| lung | 96% | 80.05 | 555 / 578 | 14% | 6.32 | 157 / 1155 |
| ureter | 0% | 0 | 0 / 0 | 100% | 49.73 | 1 / 1 |
| bladder | 52% | 41.52 | 11 / 21 | 29% | 29.37 | 147 / 504 |
| thymus | 79% | 105.74 | 515 / 653 | 0% | 0.73 | 1 / 605 |
| esophagus | 28% | 13.10 | 406 / 1445 | 39% | 26.54 | 72 / 183 |
| pancreas | 9% | 2.50 | 30 / 328 | 58% | 21.86 | 103 / 178 |
| uterus | 43% | 194.92 | 73 / 170 | 8% | 4.32 | 39 / 459 |
| spleen | 36% | 5.93 | 86 / 241 | 0% | 0 | 0 / 0 |
| ovary | 22% | 43.04 | 40 / 180 | 3% | 2.65 | 14 / 430 |
| brain | 25% | 5.02 | 670 / 2642 | 0% | 0 | 0 / 705 |
| blood vessel | 17% | 4.16 | 230 / 1335 | 0% | 0 | 0 / 0 |
| adrenal gland | 17% | 2.93 | 43 / 258 | 0% | 0 | 0 / 230 |
| muscle | 16% | 3.86 | 132 / 803 | 0% | 0 | 0 / 0 |
| adipose | 12% | 2.11 | 143 / 1204 | 0% | 0 | 0 / 0 |
| heart | 10% | 2.01 | 89 / 861 | 0% | 0 | 0 / 0 |
| breast | 8% | 7.46 | 39 / 459 | 0% | 0.01 | 1 / 1118 |
| skin | 6% | 0.92 | 111 / 1809 | 0% | 0 | 0 / 472 |
| peripheral blood | 3% | 0.49 | 32 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| GO_0032355 | Biological process | response to estradiol |
| GO_0048074 | Biological process | negative regulation of eye pigmentation |
| GO_0010468 | Biological process | regulation of gene expression |
| GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
| GO_0007224 | Biological process | smoothened signaling pathway |
| GO_0046639 | Biological process | negative regulation of alpha-beta T cell differentiation |
| GO_0003413 | Biological process | chondrocyte differentiation involved in endochondral bone morphogenesis |
| GO_0060220 | Biological process | camera-type eye photoreceptor cell fate commitment |
| GO_0001708 | Biological process | cell fate specification |
| GO_0006029 | Biological process | proteoglycan metabolic process |
| GO_0048596 | Biological process | embryonic camera-type eye morphogenesis |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0031016 | Biological process | pancreas development |
| GO_0001947 | Biological process | heart looping |
| GO_0001649 | Biological process | osteoblast differentiation |
| GO_0061053 | Biological process | somite development |
| GO_0003406 | Biological process | retinal pigment epithelium development |
| GO_0016540 | Biological process | protein autoprocessing |
| GO_0042733 | Biological process | embryonic digit morphogenesis |
| GO_0035988 | Biological process | chondrocyte proliferation |
| GO_0003382 | Biological process | epithelial cell morphogenesis |
| GO_0035264 | Biological process | multicellular organism growth |
| GO_0072498 | Biological process | embryonic skeletal joint development |
| GO_0033085 | Biological process | negative regulation of T cell differentiation in thymus |
| GO_0007267 | Biological process | cell-cell signaling |
| GO_0032331 | Biological process | negative regulation of chondrocyte differentiation |
| GO_0045880 | Biological process | positive regulation of smoothened signaling pathway |
| GO_0001569 | Biological process | branching involved in blood vessel morphogenesis |
| GO_0002053 | Biological process | positive regulation of mesenchymal cell proliferation |
| GO_0009880 | Biological process | embryonic pattern specification |
| GO_0050679 | Biological process | positive regulation of epithelial cell proliferation |
| GO_0097421 | Biological process | liver regeneration |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0032967 | Biological process | positive regulation of collagen biosynthetic process |
| GO_0048557 | Biological process | embryonic digestive tract morphogenesis |
| GO_0048666 | Biological process | neuron development |
| GO_0097264 | Biological process | self proteolysis |
| GO_0016539 | Biological process | intein-mediated protein splicing |
| GO_0045453 | Biological process | bone resorption |
| GO_0030704 | Biological process | vitelline membrane formation |
| GO_0001501 | Biological process | skeletal system development |
| GO_0033089 | Biological process | positive regulation of T cell differentiation in thymus |
| GO_0009612 | Biological process | response to mechanical stimulus |
| GO_0033088 | Biological process | negative regulation of immature T cell proliferation in thymus |
| GO_0090136 | Biological process | epithelial cell-cell adhesion |
| GO_0046638 | Biological process | positive regulation of alpha-beta T cell differentiation |
| GO_0060323 | Biological process | head morphogenesis |
| GO_0048469 | Biological process | cell maturation |
| GO_0040008 | Biological process | regulation of growth |
| GO_0048745 | Biological process | smooth muscle tissue development |
| GO_0060135 | Biological process | maternal process involved in female pregnancy |
| GO_0005615 | Cellular component | extracellular space |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0031012 | Cellular component | extracellular matrix |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0008233 | Molecular function | peptidase activity |
| GO_0005113 | Molecular function | patched binding |
| GO_0140853 | Molecular function | cholesterol-protein transferase activity |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | IHH |
| Protein name | Uncharacterized protein IHH Indian hedgehog protein (IHH) (EC 3.1.-.-) (HHG-2) [Cleaved into: Indian hedgehog protein N-product] |
| Synonyms | |
| Description | FUNCTION: [Indian hedgehog protein]: The C-terminal part of the indian hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Plays a role in hedgehog paracrine signaling . Associated with the very-low-density lipoprotein (VLDL) particles to function as a circulating morphogen for endothelial cell integrity maintenance . .; FUNCTION: [Indian hedgehog protein N-product]: The dually lipidated indian hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. Binds to the patched (PTCH1) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes (By similarity). Plays a role in morphogenesis of the skeleton by coordinating growth and differentiation of the endochondral skeleton (By similarity). Positively regulates PTHLH expression during endochondral bone formation preventing chondrocyte hypertrophy. In contrast, participates in normal chondrocyte proliferation in a PTHLH-independent pathway (By similarity). . |
| Accessions | Q14623 Q4ZFW8 ENST00000295731.7 |
