MGMT | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	25 studies	29% ± 10%	Explore
ciliated cell	18 studies	38% ± 16%	Explore
fibroblast	18 studies	23% ± 8%	Explore
pericyte	17 studies	21% ± 5%	Explore
natural killer cell	15 studies	20% ± 5%	Explore
B cell	14 studies	20% ± 5%	Explore
macrophage	14 studies	25% ± 8%	Explore
smooth muscle cell	12 studies	20% ± 6%	Explore
vein endothelial cell	9 studies	22% ± 8%	Explore
epithelial cell	9 studies	37% ± 17%	Explore
basal cell	8 studies	32% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	8 studies	19% ± 3%	Explore
myofibroblast cell	8 studies	20% ± 4%	Explore
astrocyte	8 studies	32% ± 13%	Explore
adipocyte	8 studies	29% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	20% ± 3%	Explore
CD8-positive, alpha-beta T cell	7 studies	22% ± 6%	Explore
microglial cell	7 studies	25% ± 6%	Explore
memory B cell	7 studies	17% ± 2%	Explore
endothelial cell of vascular tree	7 studies	22% ± 6%	Explore
CD4-positive, alpha-beta T cell	6 studies	19% ± 4%	Explore
epithelial cell of proximal tubule	6 studies	23% ± 3%	Explore
connective tissue cell	6 studies	22% ± 6%	Explore
mature NK T cell	5 studies	20% ± 5%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	19% ± 4%	Explore
lymphocyte	5 studies	22% ± 6%	Explore
endothelial cell of lymphatic vessel	5 studies	18% ± 2%	Explore
abnormal cell	5 studies	27% ± 18%	Explore
regulatory T cell	5 studies	20% ± 2%	Explore
hepatocyte	5 studies	67% ± 18%	Explore
type I pneumocyte	5 studies	22% ± 4%	Explore
hematopoietic precursor cell	4 studies	31% ± 12%	Explore
non-classical monocyte	4 studies	25% ± 8%	Explore
classical monocyte	4 studies	24% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	4 studies	19% ± 3%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	18% ± 1%	Explore
endothelial cell of artery	4 studies	25% ± 9%	Explore
plasma cell	4 studies	26% ± 9%	Explore
club cell	4 studies	22% ± 5%	Explore
GABAergic neuron	4 studies	34% ± 14%	Explore
goblet cell	4 studies	23% ± 7%	Explore
T cell	4 studies	17% ± 2%	Explore
mesothelial cell	4 studies	30% ± 12%	Explore
oligodendrocyte	4 studies	27% ± 7%	Explore
mast cell	4 studies	17% ± 2%	Explore
renal principal cell	4 studies	25% ± 3%	Explore
secretory cell	4 studies	32% ± 16%	Explore
deuterosomal cell	3 studies	25% ± 1%	Explore
exhausted T cell	3 studies	20% ± 5%	Explore
renal alpha-intercalated cell	3 studies	21% ± 8%	Explore
precursor B cell	3 studies	27% ± 9%	Explore
pro-B cell	3 studies	36% ± 5%	Explore
monocyte	3 studies	20% ± 3%	Explore
mucosal invariant T cell	3 studies	17% ± 0%	Explore
myeloid cell	3 studies	21% ± 5%	Explore
capillary endothelial cell	3 studies	24% ± 7%	Explore
muscle cell	3 studies	23% ± 6%	Explore
type II pneumocyte	3 studies	21% ± 4%	Explore
glutamatergic neuron	3 studies	55% ± 7%	Explore
oligodendrocyte precursor cell	3 studies	23% ± 5%	Explore
enteroendocrine cell	3 studies	30% ± 7%	Explore
intestinal crypt stem cell	3 studies	21% ± 4%	Explore
alveolar macrophage	3 studies	20% ± 6%	Explore
transit amplifying cell	3 studies	34% ± 20%	Explore
hematopoietic stem cell	3 studies	19% ± 0%	Explore
plasmacytoid dendritic cell	3 studies	21% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	19% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	20% ± 4%	Explore
gamma-delta T cell	3 studies	31% ± 19%	Explore
neuron	3 studies	41% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	7 studies	27% ± 14%	Explore
kidney	6 studies	19% ± 3%	Explore
peripheral blood	5 studies	25% ± 10%	Explore
brain	5 studies	35% ± 10%	Explore
liver	5 studies	38% ± 13%	Explore
intestine	5 studies	22% ± 10%	Explore
adipose	4 studies	21% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
thymus	100%	1260.46	653 / 653	100%	21.08	604 / 605
prostate	100%	1190.49	245 / 245	100%	22.44	501 / 502
ovary	100%	1210.25	180 / 180	100%	15.24	429 / 430
liver	100%	3353.28	226 / 226	100%	33.67	405 / 406
pancreas	100%	883.23	328 / 328	99%	15.68	176 / 178
kidney	100%	1529.02	89 / 89	99%	15.91	890 / 901
breast	100%	1577.20	459 / 459	98%	17.45	1100 / 1118
uterus	100%	1107.35	170 / 170	97%	18.43	444 / 459
lung	100%	911.20	577 / 578	94%	11.45	1086 / 1155
bladder	100%	1272.33	21 / 21	93%	16.25	470 / 504
adrenal gland	100%	1038.21	258 / 258	93%	10.74	213 / 230
stomach	100%	1034.73	359 / 359	90%	11.40	256 / 286
intestine	100%	1036.90	966 / 966	86%	12.58	455 / 527
skin	100%	1227.89	1802 / 1809	74%	8.55	351 / 472
esophagus	100%	972.20	1445 / 1445	72%	5.31	131 / 183
brain	99%	624.31	2624 / 2642	63%	4.10	442 / 705
adipose	100%	1586.91	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	21.93	29 / 29
spleen	100%	1060.23	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	12.93	1 / 1
blood vessel	100%	1054.50	1334 / 1335	0%	0	0 / 0
heart	99%	848.52	852 / 861	0%	0	0 / 0
muscle	99%	668.34	794 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	15.53	44 / 45
eye	0%	0	0 / 0	98%	22.40	78 / 80
peripheral blood	79%	568.13	738 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006307	Biological process	DNA alkylation repair
GO_0006281	Biological process	DNA repair
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0032259	Biological process	methylation
GO_2000781	Biological process	positive regulation of double-strand break repair
GO_0006266	Biological process	DNA ligation
GO_0005654	Cellular component	nucleoplasm
GO_0016020	Cellular component	membrane
GO_0005634	Cellular component	nucleus
GO_0009008	Molecular function	DNA-methyltransferase activity
GO_0003677	Molecular function	DNA binding
GO_0003908	Molecular function	methylated-DNA-[protein]-cysteine S-methyltransferase activity
GO_0046872	Molecular function	metal ion binding
GO_0008168	Molecular function	methyltransferase activity

IV. Literature review

[source]

Gene name	MGMT
Protein name	O-6-methylguanine-DNA methyltransferase (EC 2.1.1.63) Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltransferase) Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)
Synonyms
Description	FUNCTION: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. FUNCTION: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. . FUNCTION: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. . FUNCTION: Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. .
Accessions	ENST00000651593.1 A0A0G2SKF3 P16455 B4DEE8 A0A0G2SKE6 A0A059PXU1 ENST00000306010.8

MGMT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review