RICTOR | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	28 studies	36% ± 14%	Explore
natural killer cell	20 studies	25% ± 10%	Explore
T cell	15 studies	25% ± 9%	Explore
oligodendrocyte	15 studies	51% ± 16%	Explore
astrocyte	15 studies	35% ± 17%	Explore
oligodendrocyte precursor cell	14 studies	48% ± 20%	Explore
fibroblast	14 studies	28% ± 11%	Explore
B cell	13 studies	30% ± 9%	Explore
CD8-positive, alpha-beta T cell	12 studies	25% ± 10%	Explore
macrophage	12 studies	34% ± 16%	Explore
microglial cell	12 studies	45% ± 14%	Explore
GABAergic neuron	11 studies	44% ± 22%	Explore
glutamatergic neuron	11 studies	47% ± 24%	Explore
CD4-positive, alpha-beta T cell	11 studies	29% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	28% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	24% ± 9%	Explore
type I pneumocyte	9 studies	35% ± 14%	Explore
epithelial cell	9 studies	36% ± 17%	Explore
regulatory T cell	9 studies	22% ± 5%	Explore
adipocyte	9 studies	27% ± 9%	Explore
pericyte	9 studies	28% ± 12%	Explore
retinal rod cell	8 studies	41% ± 21%	Explore
smooth muscle cell	8 studies	26% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	20% ± 4%	Explore
gamma-delta T cell	8 studies	21% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	30% ± 13%	Explore
neuron	7 studies	42% ± 17%	Explore
memory B cell	7 studies	17% ± 1%	Explore
naive B cell	7 studies	19% ± 3%	Explore
basal cell	7 studies	37% ± 20%	Explore
retinal cone cell	7 studies	48% ± 17%	Explore
dendritic cell	7 studies	36% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	6 studies	28% ± 9%	Explore
mesothelial cell	6 studies	33% ± 14%	Explore
amacrine cell	6 studies	28% ± 11%	Explore
interneuron	6 studies	55% ± 22%	Explore
myeloid cell	6 studies	28% ± 5%	Explore
mast cell	6 studies	24% ± 9%	Explore
ciliated cell	6 studies	33% ± 9%	Explore
endothelial cell of lymphatic vessel	6 studies	35% ± 13%	Explore
type II pneumocyte	6 studies	35% ± 11%	Explore
plasmacytoid dendritic cell	6 studies	23% ± 7%	Explore
non-classical monocyte	5 studies	28% ± 14%	Explore
capillary endothelial cell	5 studies	26% ± 7%	Explore
retinal bipolar neuron	5 studies	23% ± 4%	Explore
retinal ganglion cell	5 studies	36% ± 20%	Explore
cardiac muscle cell	5 studies	52% ± 12%	Explore
endothelial cell of artery	5 studies	21% ± 6%	Explore
Mueller cell	5 studies	31% ± 17%	Explore
monocyte	5 studies	32% ± 6%	Explore
club cell	5 studies	33% ± 11%	Explore
classical monocyte	4 studies	27% ± 11%	Explore
mature NK T cell	4 studies	29% ± 7%	Explore
granule cell	4 studies	41% ± 10%	Explore
lymphocyte	4 studies	45% ± 18%	Explore
retina horizontal cell	4 studies	29% ± 14%	Explore
innate lymphoid cell	4 studies	18% ± 3%	Explore
neutrophil	4 studies	20% ± 1%	Explore
brush cell	4 studies	39% ± 16%	Explore
goblet cell	4 studies	36% ± 30%	Explore
CD4-positive, alpha-beta memory T cell	4 studies	19% ± 3%	Explore
plasmablast	3 studies	24% ± 10%	Explore
GABAergic interneuron	3 studies	38% ± 5%	Explore
glial cell	3 studies	28% ± 6%	Explore
progenitor cell	3 studies	31% ± 2%	Explore
plasma cell	3 studies	35% ± 5%	Explore
mononuclear phagocyte	3 studies	27% ± 5%	Explore
mucosal invariant T cell	3 studies	27% ± 8%	Explore
vein endothelial cell	3 studies	39% ± 19%	Explore
GABAergic amacrine cell	3 studies	37% ± 14%	Explore
OFF-bipolar cell	3 studies	35% ± 14%	Explore
ON-bipolar cell	3 studies	29% ± 12%	Explore
glycinergic amacrine cell	3 studies	30% ± 8%	Explore
rod bipolar cell	3 studies	36% ± 18%	Explore
endothelial cell of vascular tree	3 studies	41% ± 21%	Explore
hepatocyte	3 studies	47% ± 17%	Explore
connective tissue cell	3 studies	19% ± 1%	Explore
ependymal cell	3 studies	36% ± 14%	Explore
adventitial cell	3 studies	21% ± 6%	Explore
alveolar macrophage	3 studies	35% ± 10%	Explore
erythrocyte	3 studies	43% ± 12%	Explore
respiratory goblet cell	3 studies	35% ± 13%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 4%	Explore
leukocyte	3 studies	55% ± 11%	Explore
mural cell	3 studies	41% ± 21%	Explore
mucus secreting cell	3 studies	28% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	17 studies	44% ± 22%	Explore
lung	8 studies	27% ± 9%	Explore
eye	8 studies	39% ± 19%	Explore
peripheral blood	6 studies	27% ± 11%	Explore
heart	5 studies	33% ± 10%	Explore
liver	4 studies	31% ± 13%	Explore
intestine	3 studies	19% ± 5%	Explore
adipose	3 studies	31% ± 4%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	4786.11	578 / 578	100%	12.11	1155 / 1155
esophagus	100%	2796.41	1444 / 1445	100%	17.38	183 / 183
prostate	100%	2792.83	245 / 245	100%	8.58	500 / 502
ovary	100%	3730.22	180 / 180	100%	5.80	428 / 430
pancreas	100%	1676.39	327 / 328	99%	9.42	177 / 178
breast	100%	3829.78	459 / 459	99%	11.93	1107 / 1118
thymus	100%	3428.33	653 / 653	99%	9.29	598 / 605
kidney	100%	1845.70	89 / 89	99%	9.79	889 / 901
brain	99%	2329.63	2613 / 2642	100%	14.90	702 / 705
uterus	100%	4453.63	170 / 170	98%	9.65	448 / 459
adrenal gland	100%	1989.11	258 / 258	97%	7.02	222 / 230
bladder	100%	3406.10	21 / 21	96%	8.39	485 / 504
stomach	100%	2402.40	359 / 359	95%	8.92	272 / 286
intestine	100%	3301.56	966 / 966	95%	7.09	499 / 527
skin	100%	3475.16	1809 / 1809	91%	8.92	428 / 472
liver	100%	1403.24	226 / 226	87%	4.81	355 / 406
blood vessel	100%	3663.54	1335 / 1335	0%	0	0 / 0
muscle	100%	3183.58	803 / 803	0%	0	0 / 0
spleen	100%	3643.68	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	9.50	45 / 45
ureter	0%	0	0 / 0	100%	2.56	1 / 1
adipose	100%	3544.23	1203 / 1204	0%	0	0 / 0
heart	98%	2287.35	844 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	5.85	28 / 29
peripheral blood	92%	2699.86	859 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	57%	3.30	46 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051896	Biological process	regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0018105	Biological process	peptidyl-serine phosphorylation
GO_0010468	Biological process	regulation of gene expression
GO_0030838	Biological process	positive regulation of actin filament polymerization
GO_0033135	Biological process	regulation of peptidyl-serine phosphorylation
GO_2000114	Biological process	regulation of establishment of cell polarity
GO_0030307	Biological process	positive regulation of cell growth
GO_0009792	Biological process	embryo development ending in birth or egg hatching
GO_0007010	Biological process	cytoskeleton organization
GO_0050727	Biological process	regulation of inflammatory response
GO_0038203	Biological process	TORC2 signaling
GO_0031669	Biological process	cellular response to nutrient levels
GO_0030036	Biological process	actin cytoskeleton organization
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0001938	Biological process	positive regulation of endothelial cell proliferation
GO_0050731	Biological process	positive regulation of peptidyl-tyrosine phosphorylation
GO_0051897	Biological process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0032008	Biological process	positive regulation of TOR signaling
GO_0032956	Biological process	regulation of actin cytoskeleton organization
GO_0031932	Cellular component	TORC2 complex
GO_0005794	Cellular component	Golgi apparatus
GO_0005829	Cellular component	cytosol
GO_0060090	Molecular function	molecular adaptor activity
GO_0043022	Molecular function	ribosome binding
GO_0019901	Molecular function	protein kinase binding
GO_0043539	Molecular function	protein serine/threonine kinase activator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	RICTOR
Protein name	RPTOR independent companion of MTOR complex 2 Rapamycin-insensitive companion of mTOR (AVO3 homolog) (hAVO3) RICTOR protein
Synonyms	KIAA1999
Description	FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. .
Accessions	ENST00000503698.2 ENST00000711063.1 ENST00000296782.9 [Q6R327-3] Q8N6M7 Q6R327 D6R9S6 ENST00000511516.5 [Q6R327-4] ENST00000357387.8 [Q6R327-1] ENST00000514735.2 A0AA34QVL6 A0AA34QVX7

RICTOR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review