DMAP1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DMAP1 at tissue level.

III. Associated gene sets

GO_0006281Biological processDNA repair
GO_2000779Biological processregulation of double-strand break repair
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045471Biological processresponse to ethanol
GO_0006338Biological processchromatin remodeling
GO_0042981Biological processregulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_1905168Biological processpositive regulation of double-strand break repair via homologous recombination
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0051726Biological processregulation of cell cycle
GO_0000812Cellular componentSwr1 complex
GO_0000786Cellular componentnucleosome
GO_0005657Cellular componentreplication fork
GO_0005654Cellular componentnucleoplasm
GO_0035267Cellular componentNuA4 histone acetyltransferase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0004402Molecular functionhistone acetyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDMAP1
Protein nameDNA methyltransferase 1 associated protein 1
DNA methyltransferase 1-associated protein 1 (DNMAP1) (DNMT1-associated protein 1)
SynonymsKIAA1425
DescriptionFUNCTION: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. .

AccessionsENST00000372290.4
Q5TG38
ENST00000437511.5
Q5TG36
Q5TG37
Q5TG40
ENST00000446292.5
ENST00000440641.5
ENST00000361745.10
ENST00000436069.5
Q5TG39
ENST00000315913.9
Q9NPF5
ENST00000372289.7