NSD1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	25 studies	31% ± 14%	Explore
B cell	20 studies	23% ± 7%	Explore
natural killer cell	20 studies	22% ± 6%	Explore
fibroblast	16 studies	27% ± 11%	Explore
T cell	15 studies	21% ± 6%	Explore
oligodendrocyte	15 studies	38% ± 17%	Explore
CD8-positive, alpha-beta T cell	14 studies	21% ± 5%	Explore
astrocyte	14 studies	42% ± 17%	Explore
microglial cell	14 studies	40% ± 14%	Explore
macrophage	14 studies	32% ± 15%	Explore
oligodendrocyte precursor cell	12 studies	40% ± 18%	Explore
naive B cell	11 studies	19% ± 4%	Explore
glutamatergic neuron	11 studies	47% ± 25%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	22% ± 5%	Explore
regulatory T cell	11 studies	18% ± 3%	Explore
smooth muscle cell	11 studies	26% ± 9%	Explore
GABAergic neuron	10 studies	45% ± 24%	Explore
CD16-positive, CD56-dim natural killer cell, human	10 studies	23% ± 4%	Explore
memory B cell	10 studies	18% ± 2%	Explore
epithelial cell	9 studies	37% ± 17%	Explore
adipocyte	9 studies	43% ± 12%	Explore
dendritic cell	9 studies	34% ± 15%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	20% ± 2%	Explore
basal cell	8 studies	30% ± 15%	Explore
classical monocyte	8 studies	23% ± 9%	Explore
CD4-positive, alpha-beta T cell	8 studies	25% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	23% ± 6%	Explore
neuron	8 studies	41% ± 20%	Explore
amacrine cell	8 studies	29% ± 5%	Explore
pericyte	8 studies	27% ± 9%	Explore
myeloid cell	8 studies	30% ± 10%	Explore
plasmacytoid dendritic cell	8 studies	20% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	22% ± 7%	Explore
non-classical monocyte	7 studies	27% ± 12%	Explore
mucosal invariant T cell	7 studies	20% ± 5%	Explore
ciliated cell	7 studies	24% ± 7%	Explore
gamma-delta T cell	7 studies	22% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	20% ± 3%	Explore
abnormal cell	6 studies	25% ± 13%	Explore
interneuron	6 studies	52% ± 21%	Explore
retina horizontal cell	6 studies	29% ± 5%	Explore
retinal cone cell	6 studies	30% ± 6%	Explore
retinal rod cell	6 studies	23% ± 7%	Explore
mast cell	6 studies	26% ± 9%	Explore
endothelial cell of lymphatic vessel	6 studies	30% ± 10%	Explore
type I pneumocyte	6 studies	28% ± 8%	Explore
type II pneumocyte	6 studies	29% ± 9%	Explore
monocyte	6 studies	30% ± 11%	Explore
leukocyte	5 studies	29% ± 14%	Explore
retinal bipolar neuron	5 studies	28% ± 4%	Explore
cardiac muscle cell	5 studies	36% ± 8%	Explore
Mueller cell	5 studies	22% ± 6%	Explore
T follicular helper cell	5 studies	17% ± 0%	Explore
club cell	5 studies	29% ± 11%	Explore
hematopoietic precursor cell	4 studies	27% ± 12%	Explore
secretory cell	4 studies	21% ± 4%	Explore
mature NK T cell	4 studies	25% ± 6%	Explore
granule cell	4 studies	37% ± 7%	Explore
retinal ganglion cell	4 studies	21% ± 4%	Explore
myofibroblast cell	4 studies	29% ± 11%	Explore
plasma cell	4 studies	34% ± 12%	Explore
mesothelial cell	4 studies	32% ± 10%	Explore
lymphocyte	4 studies	37% ± 7%	Explore
respiratory goblet cell	4 studies	32% ± 13%	Explore
brush cell	4 studies	27% ± 8%	Explore
goblet cell	4 studies	28% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	17% ± 1%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	3 studies	23% ± 7%	Explore
conventional dendritic cell	3 studies	38% ± 18%	Explore
exhausted T cell	3 studies	24% ± 10%	Explore
plasmablast	3 studies	36% ± 11%	Explore
GABAergic interneuron	3 studies	36% ± 3%	Explore
glial cell	3 studies	30% ± 7%	Explore
precursor B cell	3 studies	19% ± 1%	Explore
squamous epithelial cell	3 studies	32% ± 22%	Explore
mononuclear phagocyte	3 studies	31% ± 3%	Explore
vein endothelial cell	3 studies	24% ± 12%	Explore
GABAergic amacrine cell	3 studies	26% ± 3%	Explore
OFF-bipolar cell	3 studies	25% ± 3%	Explore
ON-bipolar cell	3 studies	26% ± 4%	Explore
glycinergic amacrine cell	3 studies	27% ± 4%	Explore
rod bipolar cell	3 studies	25% ± 2%	Explore
innate lymphoid cell	3 studies	16% ± 1%	Explore
endothelial cell of vascular tree	3 studies	28% ± 13%	Explore
hepatocyte	3 studies	37% ± 11%	Explore
retinal pigment epithelial cell	3 studies	38% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	22% ± 8%	Explore
neural progenitor cell	3 studies	31% ± 8%	Explore
connective tissue cell	3 studies	25% ± 5%	Explore
ependymal cell	3 studies	41% ± 13%	Explore
alveolar macrophage	3 studies	38% ± 12%	Explore
transit amplifying cell	3 studies	38% ± 27%	Explore
mural cell	3 studies	37% ± 10%	Explore
mucus secreting cell	3 studies	30% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	22% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	40% ± 21%	Explore
lung	10 studies	23% ± 8%	Explore
peripheral blood	9 studies	22% ± 8%	Explore
eye	8 studies	27% ± 12%	Explore
heart	5 studies	29% ± 8%	Explore
liver	5 studies	28% ± 13%	Explore
adipose	4 studies	34% ± 14%	Explore
intestine	3 studies	23% ± 7%	Explore
kidney	3 studies	29% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4785.34	1445 / 1445	100%	28.23	183 / 183
breast	100%	4194.01	459 / 459	100%	29.03	1116 / 1118
thymus	100%	5719.77	653 / 653	99%	20.71	601 / 605
ovary	100%	4718.02	180 / 180	99%	19.91	427 / 430
stomach	100%	3530.36	359 / 359	99%	19.32	284 / 286
prostate	100%	4395.68	245 / 245	99%	17.99	498 / 502
intestine	100%	4985.81	966 / 966	99%	17.26	522 / 527
uterus	100%	5372.15	170 / 170	99%	21.19	453 / 459
lung	100%	4127.80	578 / 578	99%	18.21	1139 / 1155
brain	100%	3752.18	2630 / 2642	99%	17.61	697 / 705
skin	100%	5772.24	1809 / 1809	98%	18.88	464 / 472
pancreas	100%	3098.06	327 / 328	98%	15.60	174 / 178
bladder	100%	4213.57	21 / 21	97%	14.71	491 / 504
kidney	100%	3473.51	89 / 89	96%	15.96	865 / 901
adrenal gland	100%	3856.78	257 / 258	90%	9.97	208 / 230
liver	100%	1849.64	225 / 226	81%	8.06	328 / 406
adipose	100%	3992.63	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4106.35	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	20.26	29 / 29
spleen	100%	5070.55	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	26.76	45 / 45
ureter	0%	0	0 / 0	100%	4.27	1 / 1
muscle	100%	4200.16	802 / 803	0%	0	0 / 0
heart	97%	2524.89	831 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	12.03	77 / 80
peripheral blood	96%	3584.26	894 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1903025	Biological process	regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO_0033135	Biological process	regulation of peptidyl-serine phosphorylation
GO_0032259	Biological process	methylation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0006338	Biological process	chromatin remodeling
GO_0045893	Biological process	positive regulation of DNA-templated transcription
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0046966	Molecular function	nuclear thyroid hormone receptor binding
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003682	Molecular function	chromatin binding
GO_0140954	Molecular function	histone H3K36 dimethyltransferase activity
GO_0003714	Molecular function	transcription corepressor activity
GO_0003712	Molecular function	transcription coregulator activity
GO_0030331	Molecular function	nuclear estrogen receptor binding
GO_0046965	Molecular function	nuclear retinoid X receptor binding
GO_0042974	Molecular function	nuclear retinoic acid receptor binding
GO_0042799	Molecular function	histone H4K20 methyltransferase activity
GO_0008270	Molecular function	zinc ion binding
GO_0050681	Molecular function	nuclear androgen receptor binding
GO_0140938	Molecular function	histone H3 methyltransferase activity
GO_0046975	Molecular function	histone H3K36 methyltransferase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	NSD1
Protein name	Truncated nuclear receptor binding SET domain protein 1 (EC 2.1.1.354) Truncated nuclear receptor binding SET domain protein 1 (EC 2.1.1.43) Nuclear receptor binding SET domain protein 1 NSD1 protein Alternative protein NSD1 Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) Nuclear receptor SET domain-containing protein 1
Synonyms	KMT3B ARA267
Description	FUNCTION: Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. .
Accessions	ENST00000439151.7 [Q96L73-1] A4QPE5 Q96L73 H7BYB0 ENST00000375350.3 A0A1W2PS55 L0R5C2 ENST00000689326.1 A0A6C0WF95 A0A2R8Y7J4 ENST00000508029.6 B2RWP5 ENST00000689345.1 D6RG26 ENST00000354179.9 ENST00000687453.1 [Q96L73-3] ENST00000686993.1 ENST00000511258.6 A0A8I5KV31 ENST00000347982.9 D6RBP3 ENST00000638627.3 A0A8I5QJP2 A0A3G1LEI2 ENST00000644863.2 A0A410SEU7 ENST00000503056.6 ENST00000508896.7 L8EAB5

NSD1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review