NCOR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044849Biological processestrous cycle
GO_0032355Biological processresponse to estradiol
GO_1902894Biological processnegative regulation of miRNA transcription
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010243Biological processresponse to organonitrogen compound
GO_0060766Biological processnegative regulation of androgen receptor signaling pathway
GO_0021549Biological processcerebellum development
GO_0010565Biological processregulation of cellular ketone metabolic process
GO_0007595Biological processlactation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0016363Cellular componentnuclear matrix
GO_0016604Cellular componentnuclear body
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0035259Molecular functionnuclear glucocorticoid receptor binding
GO_0003682Molecular functionchromatin binding
GO_0005112Molecular functionNotch binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0046965Molecular functionnuclear retinoid X receptor binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameNCOR2
Protein nameNuclear receptor corepressor 2
Nuclear receptor corepressor 2 splice variant
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)
SynonymsCTG26
DescriptionFUNCTION: Transcriptional corepressor . Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation . .

AccessionsH7C0P3
C9JQE8
C9J330
C9J0Q5
ENST00000420698.5
H7C1J7
ENST00000440187.5
ENST00000542927.5
ENST00000429285.6
A0A481PGK9
ENST00000404621.5
ENST00000448008.1
C9JNV9
C9JE98
H7C1Y3
H7C184
ENST00000453428.1
H7C2R5
ENST00000448614.1
ENST00000418829.5
ENST00000405201.6 [Q9Y618-1]
Q9Y618
H0YGK8
ENST00000458234.5
ENST00000413172.1
H7BZU2
ENST00000440337.3