PEX14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016558Biological processprotein import into peroxisome matrix
GO_0034614Biological processcellular response to reactive oxygen species
GO_0044721Biological processprotein import into peroxisome matrix, substrate release
GO_0034453Biological processmicrotubule anchoring
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0065003Biological processprotein-containing complex assembly
GO_0036250Biological processperoxisome transport along microtubule
GO_0007031Biological processperoxisome organization
GO_0016561Biological processprotein import into peroxisome matrix, translocation
GO_0016560Biological processprotein import into peroxisome matrix, docking
GO_0032091Biological processnegative regulation of protein binding
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005778Cellular componentperoxisomal membrane
GO_0016020Cellular componentmembrane
GO_0032991Cellular componentprotein-containing complex
GO_0005777Cellular componentperoxisome
GO_0001650Cellular componentfibrillar center
GO_1990429Cellular componentperoxisomal importomer complex
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0048487Molecular functionbeta-tubulin binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0005102Molecular functionsignaling receptor binding
GO_0042802Molecular functionidentical protein binding
GO_0008320Molecular functionprotein transmembrane transporter activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePEX14
Protein namePEX14 protein
Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14)
Peroxisomal membrane protein PEX14 (Peroxin-14)
Synonyms
DescriptionFUNCTION: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor . The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix . Plays a key role for peroxisome movement through a direct interaction with tubulin . .

FUNCTION: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. .

AccessionsENST00000356607.9 [O75381-1]
K7EK59
O75381
ENST00000491661.2
Q8WVL1