Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 9 studies | 23% ± 7% | |
| adipocyte | 9 studies | 30% ± 7% | |
| glutamatergic neuron | 6 studies | 41% ± 21% | |
| retinal rod cell | 6 studies | 39% ± 15% | |
| astrocyte | 6 studies | 30% ± 10% | |
| microglial cell | 5 studies | 21% ± 4% | |
| epithelial cell | 5 studies | 26% ± 12% | |
| retinal cone cell | 5 studies | 25% ± 5% | |
| GABAergic neuron | 5 studies | 39% ± 20% | |
| macrophage | 5 studies | 22% ± 5% | |
| oligodendrocyte | 5 studies | 26% ± 8% | |
| cardiac muscle cell | 4 studies | 21% ± 1% | |
| oligodendrocyte precursor cell | 4 studies | 24% ± 6% | |
| endothelial cell of lymphatic vessel | 4 studies | 21% ± 5% | |
| interneuron | 4 studies | 37% ± 21% | |
| hepatocyte | 3 studies | 39% ± 11% | |
| T cell | 3 studies | 16% ± 1% | |
| alveolar macrophage | 3 studies | 38% ± 12% | |
| ciliated cell | 3 studies | 22% ± 4% | |
| fibroblast | 3 studies | 20% ± 5% | |
| type I pneumocyte | 3 studies | 20% ± 4% | |
| lymphocyte | 3 studies | 24% ± 6% | |
| basal cell | 3 studies | 29% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| ovary | 100% | 1268.58 | 180 / 180 | 100% | 34.79 | 430 / 430 |
| prostate | 100% | 2553.72 | 245 / 245 | 100% | 34.34 | 502 / 502 |
| thymus | 100% | 1355.00 | 653 / 653 | 100% | 35.69 | 605 / 605 |
| uterus | 100% | 1470.79 | 170 / 170 | 100% | 35.66 | 459 / 459 |
| brain | 100% | 1503.40 | 2639 / 2642 | 100% | 32.11 | 705 / 705 |
| skin | 100% | 1476.09 | 1809 / 1809 | 100% | 33.04 | 471 / 472 |
| pancreas | 100% | 553.52 | 327 / 328 | 100% | 24.84 | 178 / 178 |
| kidney | 100% | 1277.20 | 89 / 89 | 100% | 24.51 | 898 / 901 |
| intestine | 100% | 1387.27 | 966 / 966 | 100% | 24.42 | 525 / 527 |
| liver | 100% | 1542.19 | 226 / 226 | 100% | 23.35 | 404 / 406 |
| lung | 100% | 1350.84 | 578 / 578 | 99% | 25.42 | 1149 / 1155 |
| esophagus | 100% | 1527.79 | 1445 / 1445 | 99% | 22.78 | 182 / 183 |
| stomach | 100% | 975.20 | 359 / 359 | 99% | 23.35 | 284 / 286 |
| breast | 100% | 1531.11 | 459 / 459 | 99% | 25.14 | 1109 / 1118 |
| bladder | 100% | 4561.33 | 21 / 21 | 99% | 34.32 | 498 / 504 |
| adrenal gland | 100% | 1191.25 | 258 / 258 | 99% | 25.15 | 227 / 230 |
| adipose | 100% | 1411.91 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 31.06 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 26.94 | 29 / 29 |
| muscle | 100% | 1161.98 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1135.17 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 32.42 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 33.04 | 1 / 1 |
| blood vessel | 100% | 1292.97 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 98% | 1074.29 | 847 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 94% | 778.41 | 871 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0016558 | Biological process | protein import into peroxisome matrix |
| GO_0034614 | Biological process | cellular response to reactive oxygen species |
| GO_0044721 | Biological process | protein import into peroxisome matrix, substrate release |
| GO_0034453 | Biological process | microtubule anchoring |
| GO_0043433 | Biological process | negative regulation of DNA-binding transcription factor activity |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0036250 | Biological process | peroxisome transport along microtubule |
| GO_0007031 | Biological process | peroxisome organization |
| GO_0016561 | Biological process | protein import into peroxisome matrix, translocation |
| GO_0016560 | Biological process | protein import into peroxisome matrix, docking |
| GO_0032091 | Biological process | negative regulation of protein binding |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0005778 | Cellular component | peroxisomal membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005777 | Cellular component | peroxisome |
| GO_0001650 | Cellular component | fibrillar center |
| GO_1990429 | Cellular component | peroxisomal importomer complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005634 | Cellular component | nucleus |
| GO_0048487 | Molecular function | beta-tubulin binding |
| GO_0003714 | Molecular function | transcription corepressor activity |
| GO_0005102 | Molecular function | signaling receptor binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0008320 | Molecular function | protein transmembrane transporter activity |
| GO_0030674 | Molecular function | protein-macromolecule adaptor activity |
| GO_0008017 | Molecular function | microtubule binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | PEX14 |
| Protein name | PEX14 protein Peroxisomal membrane protein PEX14 (PTS1 receptor-docking protein) (Peroxin-14) (Peroxisomal membrane anchor protein PEX14) Peroxisomal membrane protein PEX14 (Peroxin-14) |
| Synonyms | |
| Description | FUNCTION: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor . The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix . Plays a key role for peroxisome movement through a direct interaction with tubulin . . FUNCTION: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor. The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm. Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. . |
| Accessions | ENST00000356607.9 [O75381-1] K7EK59 O75381 ENST00000491661.2 Q8WVL1 |