TBL1Y report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TBL1Y at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TBL1Y at tissue level.

III. Associated gene sets

GO_0048545Biological processresponse to steroid hormone
GO_0043627Biological processresponse to estrogen
GO_0045444Biological processfat cell differentiation
GO_0050821Biological processprotein stabilization
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000118Cellular componenthistone deacetylase complex
GO_0005654Cellular componentnucleoplasm
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameTBL1Y
Protein nameTransducin beta like 1 Y-linked
F-box-like/WD repeat-containing protein TBL1Y (Transducin beta-like protein 1Y) (Transducin-beta-like protein 1, Y-linked)
SynonymsTBL1
DescriptionFUNCTION: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (By similarity). .

AccessionsENST00000651523.1
Q9BQ87
ENST00000383032.6
ENST00000346432.3
A0A494C153
ENST00000355162.6