MLIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_1903243Biological processnegative regulation of cardiac muscle hypertrophy in response to stress
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010614Biological processnegative regulation of cardiac muscle hypertrophy
GO_0042383Cellular componentsarcolemma
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0005635Cellular componentnuclear envelope
GO_0031981Cellular componentnuclear lumen
GO_0005634Cellular componentnucleus
GO_0005521Molecular functionlamin binding
GO_0003714Molecular functiontranscription corepressor activity

IV. Literature review

[source]
Gene nameMLIP
Protein nameMuscular LMNA-interacting protein (Cardiac Isl1-interacting protein) (CIP) (Muscular-enriched A-type laminin-interacting protein)
Muscular LMNA interacting protein
SynonymsC6orf142
Cip
DescriptionFUNCTION: Required for myoblast differentiation into myotubes, possibly acting as a transcriptional regulator of the myogenic program (By similarity). Required for cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays a role in the protection against cardiac hypertrophy (By similarity). Binds chromatin (By similarity). May act as a transcriptional cofactor for ISL1, repressing its transcriptional activity (By similarity). May also repress MYOCD transcriptional activity (By similarity). .

AccessionsENST00000503951.5
ENST00000502396.6 [Q5VWP3-3]
ENST00000514921.5 [Q5VWP3-4]
E9PCK9
ENST00000511678.5
ENST00000370877.6
ENST00000505762.1
D6R9R6
H0Y8L5
D6RHX6
ENST00000514433.1
E9PFJ4
ENST00000447836.6
ENST00000274897.9 [Q5VWP3-1]
D6RD42
E2QRH6
Q5VWP3
ENST00000370876.6 [Q5VWP3-2]
ENST00000509997.5