YAF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0006355Biological processregulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameYAF2
Protein nameYY1 associated factor 2
YY1-associated factor 2
SynonymshCG_1997687
DescriptionFUNCTION: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. .

AccessionsF8W0B9
ENST00000548917.1
ENST00000548661.5
ENST00000547351.5
F8VZR2
A0A0B4J255
G3V1X5
F8VRE5
ENST00000547254.5
G3V219
ENST00000552109.5
ENST00000380790.4 [Q8IY57-3]
ENST00000551268.5
ENST00000534854.7 [Q8IY57-1]
Q8IY57
ENST00000546726.5
ENST00000552928.5
ENST00000327791.8 [Q8IY57-5]
ENST00000555248.2 [Q8IY57-4]
G3V212