NPAT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0044843Biological processcell cycle G1/S phase transition
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0001701Biological processin utero embryonic development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0015030Cellular componentCajal body
GO_0097504Cellular componentGemini of coiled bodies
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003713Molecular functiontranscription coactivator activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0003712Molecular functiontranscription coregulator activity

IV. Literature review

[source]
Gene nameNPAT
Protein nameNuclear protein, ataxia-telangiectasia locus
Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220)
Nuclear protein, coactivator of histone transcription
SynonymsCAND3
E14
DescriptionFUNCTION: Required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and PRKDC promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. .

AccessionsENST00000278612.9
B9EG70
Q14207
H0YET3
ENST00000527296.1
E9PKJ1
ENST00000531384.1