MTA1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0010212Biological processresponse to ionizing radiation
GO_0045475Biological processlocomotor rhythm
GO_2000736Biological processregulation of stem cell differentiation
GO_0006302Biological processdouble-strand break repair
GO_0007165Biological processsignal transduction
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0032922Biological processcircadian regulation of gene expression
GO_0042659Biological processregulation of cell fate specification
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1902499Biological processpositive regulation of protein autoubiquitination
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005874Cellular componentmicrotubule
GO_0005654Cellular componentnucleoplasm
GO_0005635Cellular componentnuclear envelope
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0016581Cellular componentNuRD complex
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0046872Molecular functionmetal ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameMTA1
Protein nameMetastasis-associated protein MTA1
Metastasis associated 1
Synonyms
DescriptionFUNCTION: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator . Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin . In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA . In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A . Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex . Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress . Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair . Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). .; FUNCTION: [Isoform Short]: Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses. .

AccessionsENST00000331320.12 [Q13330-1]
ENST00000406191.5
ENST00000438610.5 [Q13330-2]
ENST00000434050.5
ENST00000424723.5
ENST00000405646.5 [Q13330-3]
Q13330
F8W9Y9
ENST00000435036.6
ENST00000551236.5
H7C3F3
E7ESY4
H0YIT0
H0Y4T7