APEX1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045454Biological processcell redox homeostasis
GO_0006281Biological processDNA repair
GO_0043488Biological processregulation of mRNA stability
GO_0006287Biological processbase-excision repair, gap-filling
GO_0006308Biological processDNA catabolic process
GO_0042981Biological processregulation of apoptotic process
GO_0000723Biological processtelomere maintenance
GO_0044029Biological processpositive regulation of gene expression via chromosomal CpG island demethylation
GO_0006310Biological processDNA recombination
GO_0006284Biological processbase-excision repair
GO_0097698Biological processtelomere maintenance via base-excision repair
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005840Cellular componentribosome
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005739Cellular componentmitochondrion
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0090580Molecular functionphosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
GO_0004519Molecular functionendonuclease activity
GO_0052720Molecular functionclass II DNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0004844Molecular functionuracil DNA N-glycosylase activity
GO_0003906Molecular functionDNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0008296Molecular function3'-5'-DNA exonuclease activity
GO_0004523Molecular functionRNA-DNA hybrid ribonuclease activity
GO_0016890Molecular functionsite-specific endodeoxyribonuclease activity, specific for altered base
GO_0003714Molecular functiontranscription corepressor activity
GO_0008408Molecular function3'-5' exonuclease activity
GO_0016491Molecular functionoxidoreductase activity
GO_0008311Molecular functiondouble-stranded DNA 3'-5' DNA exonuclease activity
GO_0003691Molecular functiondouble-stranded telomeric DNA binding
GO_0004528Molecular functionphosphodiesterase I activity
GO_0046872Molecular functionmetal ion binding
GO_0004520Molecular functionDNA endonuclease activity
GO_0003723Molecular functionRNA binding
GO_0008081Molecular functionphosphoric diester hydrolase activity
GO_0031490Molecular functionchromatin DNA binding
GO_0140431Molecular functionDNA-(abasic site) binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0008309Molecular functiondouble-stranded DNA exodeoxyribonuclease activity
GO_0005515Molecular functionprotein binding
GO_0003684Molecular functiondamaged DNA binding

IV. Literature review

[source]
Gene nameAPEX1
Protein nameApurinic/apyrimidinic endodeoxyribonuclease 1
DNA repair nuclease/redox regulator APEX1 (EC 3.1.11.2) (EC 3.1.21.-) (APEX nuclease) (APEN) (Apurinic-apyrimidinic endonuclease 1) (AP endonuclease 1) (APE-1) (DNA-(apurinic or apyrimidinic site) endonuclease) (REF-1) (Redox factor-1) [Cleaved into: DNA repair nuclease/redox regulator APEX1, mitochondrial]
exodeoxyribonuclease III (EC 3.1.11.2)
DNA-(apurinic or apyrimidinic site) endonuclease (EC 3.1.-.-)
SynonymsAPE1
HAP1
APX
hCG_40473
APE
REF1
APEX
DescriptionFUNCTION: Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 are DNA repair and redox regulation of transcriptional factors. Functions as an apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also incises at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' side of DNA strand breaks. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Acts as a loading factor for POLB onto non-incised AP sites in DNA and stimulates the 5'-terminal deoxyribose 5'-phosphate (dRp) excision activity of POLB. Plays a role in protection from granzyme-mediated cellular repair leading to cell death. Also involved in the DNA cleavage step of class switch recombination (CSR). On the other hand, APEX1 also exerts reversible nuclear redox activity to regulate DNA binding affinity and transcriptional activity of transcriptional factors by controlling the redox status of their DNA-binding domain, such as the FOS/JUN AP-1 complex after exposure to IR. Involved in calcium-dependent down-regulation of parathyroid hormone (PTH) expression by binding to negative calcium response elements (nCaREs). Together with HNRNPL or the dimer XRCC5/XRCC6, associates with nCaRE, acting as an activator of transcriptional repression. Stimulates the YBX1-mediated MDR1 promoter activity, when acetylated at Lys-6 and Lys-7, leading to drug resistance. Acts also as an endoribonuclease involved in the control of single-stranded RNA metabolism. Plays a role in regulating MYC mRNA turnover by preferentially cleaving in between UA and CA dinucleotides of the MYC coding region determinant (CRD). In association with NMD1, plays a role in the rRNA quality control process during cell cycle progression. Associates, together with YBX1, on the MDR1 promoter. Together with NPM1, associates with rRNA. Binds DNA and RNA. .

FUNCTION: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. .

FUNCTION: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. .

FUNCTION: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. .

FUNCTION: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. .

FUNCTION: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. .

FUNCTION: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. .

FUNCTION: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. .

FUNCTION: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. .

AccessionsP27695
G3V3M6
G3V3C7
ENST00000557054.1
G3V574
ENST00000553681.5
G3V359
ENST00000438886.1
ENST00000216714.8
ENST00000708795.1
G3V5Q1
ENST00000555414.5
A0A0C4DGK8
Q5TZP7
ENST00000554325.1
G3V2D9
ENST00000557181.5
G3V3Y6
G3V5D9
ENST00000708794.1
ENST00000708787.1
ENST00000555839.5
G3V5M0
ENST00000557150.5
ENST00000553368.1
ENST00000557344.5
ENST00000557592.5
ENST00000398030.8
ENST00000556054.5
H7C4A8