SAP18 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0008380Biological processRNA splicing
GO_0048025Biological processnegative regulation of mRNA splicing, via spliceosome
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0016607Cellular componentnuclear speck
GO_0035145Cellular componentexon-exon junction complex
GO_0005654Cellular componentnucleoplasm
GO_0000118Cellular componenthistone deacetylase complex
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0061574Cellular componentASAP complex
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSAP18
Protein name18 kDa Sin3-associated polypeptide
Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (2HOR0202) (Cell growth-inhibiting gene 38 protein) (Sin3-associated polypeptide p18)
SynonymsGIG38
DescriptionFUNCTION: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. .

AccessionsENST00000607003.5 [O00422-1]
ENST00000450573.5
U3KPY7
ENST00000492245.5
ENST00000467636.1
ENST00000382533.9 [O00422-2]
H7BZW6
U3KQ12
O00422
ENST00000621421.4 [O00422-2]