ARID5A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1901985Biological processpositive regulation of protein acetylation
GO_2000556Biological processpositive regulation of T-helper 1 cell cytokine production
GO_0045087Biological processinnate immune response
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000318Biological processpositive regulation of T-helper 17 type immune response
GO_0002062Biological processchondrocyte differentiation
GO_0071391Biological processcellular response to estrogen stimulus
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0032729Biological processpositive regulation of type II interferon production
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0032740Biological processpositive regulation of interleukin-17 production
GO_0032755Biological processpositive regulation of interleukin-6 production
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0046966Molecular functionnuclear thyroid hormone receptor binding
GO_0003677Molecular functionDNA binding
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0042802Molecular functionidentical protein binding
GO_0030331Molecular functionnuclear estrogen receptor binding
GO_0046965Molecular functionnuclear retinoid X receptor binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0035613Molecular functionRNA stem-loop binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARID5A
Protein nameAT-rich interaction domain 5A
AT-rich interactive domain-containing protein 5A (ARID domain-containing protein 5A) (Modulator recognition factor 1) (MRF-1)
SynonymsMRF1
DescriptionFUNCTION: Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison . May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention (By similarity). Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors . As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock (By similarity). Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A (By similarity). .

AccessionsENST00000357485.8 [Q03989-1]
F6Q9D3
ENST00000454558.2 [Q03989-5]
ENST00000412735.5
A0A669KBH0
Q03989
ENST00000673792.1