NCOR1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	44 studies	36% ± 16%	Explore
B cell	40 studies	33% ± 9%	Explore
fibroblast	39 studies	32% ± 14%	Explore
natural killer cell	37 studies	35% ± 8%	Explore
CD8-positive, alpha-beta T cell	33 studies	32% ± 8%	Explore
macrophage	32 studies	29% ± 15%	Explore
pericyte	32 studies	33% ± 13%	Explore
CD4-positive, alpha-beta T cell	32 studies	30% ± 8%	Explore
T cell	31 studies	33% ± 10%	Explore
smooth muscle cell	29 studies	31% ± 11%	Explore
regulatory T cell	27 studies	35% ± 9%	Explore
mast cell	22 studies	27% ± 8%	Explore
classical monocyte	21 studies	27% ± 11%	Explore
conventional dendritic cell	20 studies	27% ± 15%	Explore
mature NK T cell	20 studies	32% ± 8%	Explore
memory B cell	20 studies	33% ± 6%	Explore
astrocyte	20 studies	46% ± 18%	Explore
naive B cell	19 studies	30% ± 6%	Explore
basal cell	18 studies	35% ± 18%	Explore
non-classical monocyte	18 studies	28% ± 11%	Explore
monocyte	17 studies	33% ± 15%	Explore
epithelial cell	17 studies	39% ± 22%	Explore
gamma-delta T cell	17 studies	39% ± 12%	Explore
microglial cell	17 studies	44% ± 16%	Explore
endothelial cell of lymphatic vessel	16 studies	35% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	36% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	29% ± 7%	Explore
oligodendrocyte precursor cell	16 studies	43% ± 18%	Explore
plasmacytoid dendritic cell	15 studies	31% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	39% ± 7%	Explore
oligodendrocyte	15 studies	44% ± 16%	Explore
capillary endothelial cell	15 studies	26% ± 7%	Explore
ciliated cell	14 studies	33% ± 11%	Explore
myofibroblast cell	14 studies	35% ± 14%	Explore
mucosal invariant T cell	14 studies	31% ± 6%	Explore
dendritic cell	13 studies	37% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	36% ± 11%	Explore
connective tissue cell	13 studies	32% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	31% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	32% ± 7%	Explore
glutamatergic neuron	12 studies	52% ± 24%	Explore
endothelial cell of artery	12 studies	25% ± 5%	Explore
plasma cell	11 studies	30% ± 11%	Explore
GABAergic neuron	11 studies	48% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	37% ± 5%	Explore
vein endothelial cell	11 studies	29% ± 15%	Explore
myeloid cell	11 studies	35% ± 13%	Explore
type I pneumocyte	10 studies	37% ± 9%	Explore
neuron	10 studies	48% ± 20%	Explore
endothelial cell of vascular tree	10 studies	29% ± 16%	Explore
type II pneumocyte	9 studies	34% ± 13%	Explore
club cell	9 studies	37% ± 13%	Explore
leukocyte	9 studies	37% ± 15%	Explore
progenitor cell	9 studies	28% ± 6%	Explore
adipocyte	9 studies	55% ± 11%	Explore
goblet cell	8 studies	35% ± 23%	Explore
amacrine cell	8 studies	45% ± 13%	Explore
retinal rod cell	8 studies	40% ± 12%	Explore
mesothelial cell	8 studies	36% ± 13%	Explore
alveolar macrophage	7 studies	36% ± 20%	Explore
plasmablast	7 studies	42% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	30% ± 8%	Explore
abnormal cell	7 studies	35% ± 15%	Explore
retinal ganglion cell	7 studies	43% ± 16%	Explore
retinal cone cell	7 studies	50% ± 13%	Explore
T follicular helper cell	7 studies	29% ± 5%	Explore
respiratory goblet cell	6 studies	42% ± 13%	Explore
secretory cell	6 studies	29% ± 11%	Explore
kidney loop of Henle epithelial cell	6 studies	25% ± 8%	Explore
renal alpha-intercalated cell	6 studies	35% ± 11%	Explore
enterocyte	6 studies	25% ± 5%	Explore
transit amplifying cell	6 studies	31% ± 26%	Explore
interneuron	6 studies	62% ± 19%	Explore
hematopoietic stem cell	6 studies	28% ± 10%	Explore
lymphocyte	6 studies	41% ± 17%	Explore
precursor B cell	6 studies	38% ± 11%	Explore
retina horizontal cell	6 studies	43% ± 9%	Explore
Mueller cell	6 studies	40% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	33% ± 9%	Explore
innate lymphoid cell	6 studies	33% ± 7%	Explore
hematopoietic precursor cell	5 studies	41% ± 15%	Explore
exhausted T cell	5 studies	41% ± 9%	Explore
platelet	5 studies	22% ± 1%	Explore
mononuclear phagocyte	5 studies	34% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	28% ± 8%	Explore
enteroendocrine cell	5 studies	30% ± 13%	Explore
retinal bipolar neuron	5 studies	41% ± 8%	Explore
pro-B cell	5 studies	33% ± 7%	Explore
brush cell	5 studies	35% ± 6%	Explore
cardiac muscle cell	5 studies	39% ± 7%	Explore
hepatocyte	5 studies	55% ± 25%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	35% ± 4%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	46% ± 6%	Explore
glial cell	4 studies	39% ± 13%	Explore
granule cell	4 studies	44% ± 6%	Explore
megakaryocyte	4 studies	35% ± 9%	Explore
immature B cell	4 studies	35% ± 6%	Explore
retinal pigment epithelial cell	4 studies	45% ± 23%	Explore
OFF-bipolar cell	4 studies	34% ± 7%	Explore
ON-bipolar cell	4 studies	34% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	37% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	33% ± 11%	Explore
muscle cell	4 studies	46% ± 20%	Explore
T-helper 17 cell	4 studies	26% ± 7%	Explore
double negative thymocyte	4 studies	46% ± 14%	Explore
renal principal cell	4 studies	39% ± 11%	Explore
ionocyte	3 studies	34% ± 4%	Explore
pancreatic A cell	3 studies	49% ± 15%	Explore
type B pancreatic cell	3 studies	47% ± 19%	Explore
podocyte	3 studies	32% ± 5%	Explore
epithelial cell of proximal tubule	3 studies	30% ± 7%	Explore
intestinal crypt stem cell	3 studies	25% ± 4%	Explore
neural crest cell	3 studies	28% ± 4%	Explore
GABAergic interneuron	3 studies	47% ± 4%	Explore
squamous epithelial cell	3 studies	38% ± 25%	Explore
tissue-resident macrophage	3 studies	25% ± 10%	Explore
intraepithelial lymphocyte	3 studies	38% ± 17%	Explore
GABAergic amacrine cell	3 studies	47% ± 11%	Explore
glycinergic amacrine cell	3 studies	43% ± 7%	Explore
rod bipolar cell	3 studies	48% ± 10%	Explore
erythroblast	3 studies	31% ± 17%	Explore
germinal center B cell	3 studies	27% ± 2%	Explore
CD4-positive helper T cell	3 studies	30% ± 9%	Explore
pancreatic ductal cell	3 studies	49% ± 24%	Explore
ependymal cell	3 studies	55% ± 14%	Explore
granulocyte	3 studies	34% ± 12%	Explore
neutrophil	3 studies	24% ± 11%	Explore
adventitial cell	3 studies	33% ± 5%	Explore
chondrocyte	3 studies	43% ± 12%	Explore
group 3 innate lymphoid cell	3 studies	47% ± 9%	Explore
Schwann cell	3 studies	35% ± 16%	Explore
T-helper 1 cell	3 studies	32% ± 7%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	32% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	31% ± 5%	Explore
myoepithelial cell	3 studies	38% ± 17%	Explore
mural cell	3 studies	52% ± 7%	Explore
mucus secreting cell	3 studies	42% ± 9%	Explore
erythrocyte	3 studies	32% ± 19%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	20 studies	45% ± 22%	Explore
lung	19 studies	32% ± 11%	Explore
peripheral blood	17 studies	34% ± 10%	Explore
intestine	10 studies	25% ± 11%	Explore
eye	10 studies	42% ± 18%	Explore
kidney	9 studies	29% ± 10%	Explore
liver	6 studies	39% ± 17%	Explore
heart	5 studies	34% ± 7%	Explore
breast	5 studies	24% ± 6%	Explore
bone marrow	4 studies	28% ± 10%	Explore
uterus	4 studies	30% ± 12%	Explore
lymph node	4 studies	27% ± 5%	Explore
adipose	4 studies	43% ± 13%	Explore
pancreas	3 studies	48% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6897.54	1445 / 1445	100%	46.62	183 / 183
prostate	100%	7211.88	245 / 245	100%	26.97	502 / 502
thymus	100%	7657.91	653 / 653	100%	28.41	604 / 605
brain	100%	5742.02	2641 / 2642	100%	26.70	704 / 705
uterus	100%	8520.94	170 / 170	100%	19.66	458 / 459
intestine	100%	8053.06	966 / 966	100%	28.28	525 / 527
pancreas	100%	3790.74	328 / 328	99%	21.04	177 / 178
breast	100%	7017.65	459 / 459	99%	33.27	1109 / 1118
ovary	100%	7496.22	180 / 180	99%	19.63	426 / 430
lung	100%	6642.09	578 / 578	99%	25.86	1144 / 1155
stomach	100%	6500.41	359 / 359	99%	37.65	283 / 286
skin	100%	7407.85	1809 / 1809	98%	22.91	463 / 472
bladder	100%	7884.05	21 / 21	98%	19.77	494 / 504
kidney	100%	6135.52	89 / 89	98%	26.48	883 / 901
adrenal gland	100%	5444.37	258 / 258	89%	12.00	204 / 230
liver	100%	4108.72	226 / 226	81%	10.66	330 / 406
adipose	100%	6592.27	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7821.67	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	18.11	29 / 29
muscle	100%	6965.92	803 / 803	0%	0	0 / 0
spleen	100%	6041.10	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	24.42	45 / 45
ureter	0%	0	0 / 0	100%	5.11	1 / 1
heart	98%	3701.20	847 / 861	0%	0	0 / 0
peripheral blood	98%	5093.59	909 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	96%	16.45	77 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006325	Biological process	chromatin organization
GO_0045475	Biological process	locomotor rhythm
GO_1902894	Biological process	negative regulation of miRNA transcription
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0045820	Biological process	negative regulation of glycolytic process
GO_0045922	Biological process	negative regulation of fatty acid metabolic process
GO_0051225	Biological process	spindle assembly
GO_0046329	Biological process	negative regulation of JNK cascade
GO_0060766	Biological process	negative regulation of androgen receptor signaling pathway
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0072686	Cellular component	mitotic spindle
GO_0016020	Cellular component	membrane
GO_0005654	Cellular component	nucleoplasm
GO_0017053	Cellular component	transcription repressor complex
GO_0000118	Cellular component	histone deacetylase complex
GO_0005829	Cellular component	cytosol
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0046966	Molecular function	nuclear thyroid hormone receptor binding
GO_0016922	Molecular function	nuclear receptor binding
GO_0000976	Molecular function	transcription cis-regulatory region binding
GO_0003714	Molecular function	transcription corepressor activity
GO_0061629	Molecular function	RNA polymerase II-specific DNA-binding transcription factor binding
GO_0005515	Molecular function	protein binding
GO_0042826	Molecular function	histone deacetylase binding

IV. Literature review

[source]

Gene name	NCOR1
Protein name	Nuclear receptor corepressor 1 Nuclear receptor corepressor 1 (N-CoR) (N-CoR1)
Synonyms	KIAA1047
Description	FUNCTION: Mediates transcriptional repression by certain nuclear receptors . Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation . Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity). .
Accessions	Q3B773 S4R380 ENST00000603989.1 Q86W52 ENST00000436828.5 A0A994J5B8 ENST00000704744.1 ENST00000582357.5 A5PKW7 ENST00000460276.5 ENST00000430577.2 O75376 ENST00000395851.5 [O75376-2] ENST00000268712.8 [O75376-1] Q05CG3 Q6PDT8 ENST00000579573.2 C9JAP0 ENST00000580554.1 J3KT44 E7EVK1 J3QKP0 ENST00000579606.1 J3KS29 ENST00000436068.2 H0Y459 ENST00000411510.5 Q6NTH1 ENST00000395849.6 ENST00000395848.5 [O75376-3] Q6PGR4 E7EW50 E7EVU5 ENST00000704745.1 J3KRE4 J3KS51

NCOR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review