BRD7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_0006338Biological processchromatin remodeling
GO_0070316Biological processregulation of G0 to G1 transition
GO_0045597Biological processpositive regulation of cell differentiation
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007346Biological processregulation of mitotic cell cycle
GO_2000819Biological processregulation of nucleotide-excision repair
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0016055Biological processWnt signaling pathway
GO_2000781Biological processpositive regulation of double-strand break repair
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0000776Cellular componentkinetochore
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0016586Cellular componentRSC-type complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042393Molecular functionhistone binding
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0002039Molecular functionp53 binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBRD7
Protein nameBromodomain containing 7
Bromodomain-containing protein 7 (75 kDa bromodomain protein) (Protein CELTIX-1)
SynonymsCELTIX1
BP75
DescriptionFUNCTION: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. .

AccessionsENST00000394688.8 [Q9NPI1-1]
ENST00000710357.1
A0AA34QW01
ENST00000569774.6
A0AA34QVS2
ENST00000562383.6
Q9NPI1
I3L0Y7
I3L4V5
ENST00000710356.1
ENST00000394689.2 [Q9NPI1-2]