Tissue | GTEx Coverage  | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| bladder | 100% | 3933.14 | 21 / 21 | 100% | 55.73 | 504 / 504 |
| breast | 100% | 3443.25 | 459 / 459 | 100% | 65.48 | 1118 / 1118 |
| esophagus | 100% | 3144.29 | 1445 / 1445 | 100% | 64.70 | 183 / 183 |
| ovary | 100% | 4168.84 | 180 / 180 | 100% | 77.27 | 430 / 430 |
| pancreas | 100% | 2130.87 | 328 / 328 | 100% | 40.72 | 178 / 178 |
| prostate | 100% | 3917.16 | 245 / 245 | 100% | 65.35 | 502 / 502 |
| stomach | 100% | 2445.77 | 359 / 359 | 100% | 58.94 | 286 / 286 |
| uterus | 100% | 3317.85 | 170 / 170 | 100% | 55.62 | 459 / 459 |
| brain | 100% | 3074.32 | 2641 / 2642 | 100% | 45.06 | 705 / 705 |
| lung | 100% | 2721.71 | 577 / 578 | 100% | 55.88 | 1155 / 1155 |
| intestine | 100% | 3360.70 | 966 / 966 | 100% | 56.10 | 526 / 527 |
| thymus | 100% | 3674.81 | 653 / 653 | 100% | 51.76 | 603 / 605 |
| liver | 100% | 1520.38 | 226 / 226 | 99% | 25.42 | 403 / 406 |
| kidney | 100% | 2652.76 | 89 / 89 | 99% | 33.30 | 891 / 901 |
| adrenal gland | 100% | 4229.66 | 258 / 258 | 98% | 40.78 | 225 / 230 |
| skin | 100% | 4403.92 | 1809 / 1809 | 98% | 45.90 | 461 / 472 |
| adipose | 100% | 3333.56 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3417.25 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 35.52 | 29 / 29 |
| muscle | 100% | 4094.14 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2793.53 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 41.41 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 20.19 | 1 / 1 |
| heart | 95% | 1988.86 | 819 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 95% | 30.80 | 76 / 80 |
| peripheral blood | 62% | 1567.55 | 572 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0001558 | Biological process | regulation of cell growth |
| GO_0010923 | Biological process | negative regulation of phosphatase activity |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0009615 | Biological process | response to virus |
| GO_0071383 | Biological process | cellular response to steroid hormone stimulus |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0071363 | Biological process | cellular response to growth factor stimulus |
| GO_0050821 | Biological process | protein stabilization |
| GO_2001243 | Biological process | negative regulation of intrinsic apoptotic signaling pathway |
| GO_1990062 | Cellular component | RPAP3/R2TP/prefoldin-like complex |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0030425 | Cellular component | dendrite |
| GO_0101031 | Cellular component | protein folding chaperone complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0003714 | Molecular function | transcription corepressor activity |
| GO_0004864 | Molecular function | protein phosphatase inhibitor activity |
| GO_0000993 | Molecular function | RNA polymerase II complex binding |
| GO_0051219 | Molecular function | phosphoprotein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0019212 | Molecular function | phosphatase inhibitor activity |
| Gene name | URI1 |
| Protein name | Unconventional prefoldin RPB5 interactor 1 (Protein NNX3) (Protein phosphatase 1 regulatory subunit 19) (RNA polymerase II subunit 5-mediating protein) (RPB5-mediating protein) URI1 prefoldin like chaperone |
| Synonyms | NNX3 C19orf2 URI RMP PPP1R19 |
| Description | FUNCTION: Involved in gene transcription regulation. Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription. May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells. Required for cell survival in ovarian cancer cells. Together with UXT, associates with chromatin to the NKX3-1 promoter region. Antagonizes transcriptional modulation via hepatitis B virus X protein.; FUNCTION: Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling. The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors. Mediates inhibition of PPP1CC phosphatase activity in mitochondria. Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner. Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination. |
| Accessions | ENST00000585655.1 I3L104 ENST00000574666.5 ENST00000575242.1 ENST00000360605.8 [O94763-4] I3L0K5 O94763 ENST00000574233.5 K7EQZ9 I3L280 I3L467 ENST00000576442.1 ENST00000570564.5 I3L2V7 I3NI51 ENST00000573052.1 ENST00000392271.6 [O94763-1] ENST00000574110.5 I3L130 |
