PRMT5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of PRMT5 at tissue level.

III. Associated gene sets

GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0000387Biological processspliceosomal snRNP assembly
GO_0044027Biological processnegative regulation of gene expression via chromosomal CpG island methylation
GO_0048026Biological processpositive regulation of mRNA splicing, via spliceosome
GO_0042118Biological processendothelial cell activation
GO_0006338Biological processchromatin remodeling
GO_0032922Biological processcircadian regulation of gene expression
GO_0018216Biological processpeptidyl-arginine methylation
GO_0097421Biological processliver regeneration
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_1901796Biological processregulation of signal transduction by p53 class mediator
GO_0035246Biological processpeptidyl-arginine N-methylation
GO_1904992Biological processpositive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway
GO_0006355Biological processregulation of DNA-templated transcription
GO_0045596Biological processnegative regulation of cell differentiation
GO_0006353Biological processDNA-templated transcription termination
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0090161Biological processGolgi ribbon formation
GO_0007088Biological processregulation of mitotic nuclear division
GO_0035097Cellular componenthistone methyltransferase complex
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0034709Cellular componentmethylosome
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0035243Molecular functionprotein-arginine omega-N symmetric methyltransferase activity
GO_0043021Molecular functionribonucleoprotein complex binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0042802Molecular functionidentical protein binding
GO_0042054Molecular functionhistone methyltransferase activity
GO_0008327Molecular functionmethyl-CpG binding
GO_0002039Molecular functionp53 binding
GO_0008168Molecular functionmethyltransferase activity
GO_0008469Molecular functionhistone arginine N-methyltransferase activity
GO_0046982Molecular functionprotein heterodimerization activity
GO_0016274Molecular functionprotein-arginine N-methyltransferase activity
GO_0140938Molecular functionhistone H3 methyltransferase activity
GO_0070888Molecular functionE-box binding
GO_0044020Molecular functionhistone H4R3 methyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRMT5
Protein nameProtein arginine methyltransferase 5
Protein arginine N-methyltransferase 5 (PRMT5) (EC 2.1.1.320) (72 kDa ICln-binding protein) (Histone-arginine N-methyltransferase PRMT5) (Jak-binding protein 1) (Shk1 kinase-binding protein 1 homolog) (SKB1 homolog) (SKB1Hs) [Cleaved into: Protein arginine N-methyltransferase 5, N-terminally processed]
SynonymsHRMT1L5
IBP72
JBP1
SKB1
DescriptionFUNCTION: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA . Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles . Methylates SUPT5H and may regulate its transcriptional elongation properties . May methylate the N-terminal region of MBD2 . Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10. Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation . Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity . Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 . Methylates and regulates SRGAP2 which is involved in cell migration and differentiation . Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation . Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner . Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination . Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression . Symmetrically methylates NCL . Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity . Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). .

AccessionsH0YJY6
G3V2L6
ENST00000627278.1
G3V507
ENST00000557415.5
ENST00000556616.5
ENST00000553502.5
H0YJX6
C9JSX3
ENST00000555530.5
G3V5L5
G3V2X6
H0YJD3
G3V5T6
ENST00000554867.5
ENST00000421938.2
ENST00000216350.12 [O14744-3]
ENST00000557443.5
ENST00000324366.13 [O14744-1]
G3V2F5
G3V3A3
ENST00000553915.5
G3V580
H0YJ77
ENST00000454731.6
ENST00000553897.5 [O14744-5]
ENST00000553787.5
ENST00000555454.5
ENST00000554910.5
ENST00000553550.5
ENST00000397440.8 [O14744-4]
ENST00000397441.6 [O14744-2]
H7BZ44
ENST00000556043.5
O14744