DNAJB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	37 studies	41% ± 21%	Explore
CD8-positive, alpha-beta T cell	37 studies	46% ± 22%	Explore
T cell	33 studies	45% ± 22%	Explore
CD4-positive, alpha-beta T cell	32 studies	51% ± 23%	Explore
endothelial cell	31 studies	44% ± 22%	Explore
macrophage	30 studies	49% ± 22%	Explore
fibroblast	29 studies	52% ± 21%	Explore
regulatory T cell	26 studies	51% ± 21%	Explore
B cell	23 studies	45% ± 20%	Explore
pericyte	21 studies	52% ± 23%	Explore
basal cell	21 studies	42% ± 17%	Explore
epithelial cell	21 studies	41% ± 20%	Explore
conventional dendritic cell	21 studies	45% ± 19%	Explore
mast cell	20 studies	49% ± 17%	Explore
smooth muscle cell	20 studies	52% ± 21%	Explore
mature NK T cell	19 studies	42% ± 20%	Explore
non-classical monocyte	19 studies	37% ± 15%	Explore
gamma-delta T cell	18 studies	44% ± 22%	Explore
ciliated cell	18 studies	40% ± 18%	Explore
classical monocyte	18 studies	28% ± 10%	Explore
monocyte	17 studies	48% ± 24%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	38% ± 15%	Explore
dendritic cell	16 studies	48% ± 22%	Explore
endothelial cell of lymphatic vessel	15 studies	38% ± 20%	Explore
mucosal invariant T cell	15 studies	52% ± 17%	Explore
connective tissue cell	15 studies	50% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	44% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	36% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	45% ± 20%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	50% ± 25%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	49% ± 24%	Explore
plasma cell	11 studies	47% ± 18%	Explore
secretory cell	11 studies	39% ± 16%	Explore
capillary endothelial cell	11 studies	29% ± 13%	Explore
memory B cell	11 studies	34% ± 15%	Explore
endothelial cell of vascular tree	11 studies	42% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	33% ± 20%	Explore
leukocyte	10 studies	49% ± 19%	Explore
myofibroblast cell	10 studies	49% ± 26%	Explore
innate lymphoid cell	10 studies	47% ± 16%	Explore
abnormal cell	10 studies	40% ± 19%	Explore
naive B cell	10 studies	33% ± 18%	Explore
astrocyte	9 studies	35% ± 14%	Explore
type I pneumocyte	8 studies	42% ± 19%	Explore
type II pneumocyte	8 studies	35% ± 15%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	33% ± 18%	Explore
progenitor cell	8 studies	43% ± 21%	Explore
myeloid cell	8 studies	37% ± 19%	Explore
vein endothelial cell	8 studies	26% ± 11%	Explore
endothelial cell of artery	8 studies	26% ± 10%	Explore
erythrocyte	8 studies	37% ± 20%	Explore
plasmacytoid dendritic cell	7 studies	31% ± 10%	Explore
goblet cell	7 studies	26% ± 8%	Explore
CD4-positive helper T cell	6 studies	43% ± 18%	Explore
club cell	6 studies	33% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	46% ± 19%	Explore
plasmablast	6 studies	27% ± 8%	Explore
microglial cell	6 studies	38% ± 21%	Explore
T follicular helper cell	6 studies	53% ± 23%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	44% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	5 studies	21% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	43% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	34% ± 12%	Explore
mononuclear phagocyte	5 studies	39% ± 10%	Explore
neutrophil	5 studies	33% ± 17%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	45% ± 15%	Explore
renal alpha-intercalated cell	5 studies	53% ± 21%	Explore
glial cell	5 studies	26% ± 7%	Explore
group 3 innate lymphoid cell	5 studies	65% ± 15%	Explore
neuron	5 studies	25% ± 9%	Explore
precursor B cell	5 studies	49% ± 23%	Explore
alveolar macrophage	4 studies	34% ± 12%	Explore
deuterosomal cell	4 studies	26% ± 3%	Explore
respiratory goblet cell	4 studies	39% ± 14%	Explore
squamous epithelial cell	4 studies	63% ± 8%	Explore
exhausted T cell	4 studies	38% ± 15%	Explore
epithelial cell of proximal tubule	4 studies	44% ± 16%	Explore
retinal rod cell	4 studies	27% ± 19%	Explore
hematopoietic stem cell	4 studies	17% ± 2%	Explore
lymphocyte	4 studies	34% ± 23%	Explore
pro-B cell	4 studies	34% ± 14%	Explore
enterocyte	4 studies	28% ± 5%	Explore
T-helper 17 cell	4 studies	57% ± 28%	Explore
mesothelial cell	4 studies	48% ± 23%	Explore
adventitial cell	4 studies	38% ± 10%	Explore
erythroblast	4 studies	29% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	47% ± 26%	Explore
transit amplifying cell	4 studies	25% ± 4%	Explore
keratinocyte	4 studies	49% ± 25%	Explore
IgA plasma cell	4 studies	33% ± 9%	Explore
platelet	3 studies	18% ± 0%	Explore
glomerular endothelial cell	3 studies	73% ± 12%	Explore
retinal ganglion cell	3 studies	36% ± 16%	Explore
kidney loop of Henle epithelial cell	3 studies	39% ± 14%	Explore
ionocyte	3 studies	34% ± 9%	Explore
immature B cell	3 studies	51% ± 9%	Explore
amacrine cell	3 studies	20% ± 3%	Explore
retinal cone cell	3 studies	39% ± 15%	Explore
retinal pigment epithelial cell	3 studies	53% ± 26%	Explore
duct epithelial cell	3 studies	27% ± 4%	Explore
intraepithelial lymphocyte	3 studies	36% ± 24%	Explore
muscle cell	3 studies	36% ± 10%	Explore
intermediate monocyte	3 studies	59% ± 10%	Explore
granulocyte	3 studies	41% ± 11%	Explore
luminal cell of prostate epithelium	3 studies	31% ± 5%	Explore
GABAergic neuron	3 studies	27% ± 12%	Explore
glutamatergic neuron	3 studies	35% ± 15%	Explore
pancreatic ductal cell	3 studies	51% ± 25%	Explore
oligodendrocyte precursor cell	3 studies	34% ± 5%	Explore
ependymal cell	3 studies	30% ± 13%	Explore
enteroendocrine cell	3 studies	31% ± 1%	Explore
intestinal crypt stem cell	3 studies	23% ± 7%	Explore
melanocyte	3 studies	40% ± 13%	Explore
IgG plasma cell	3 studies	36% ± 13%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	48% ± 16%	Explore
double negative thymocyte	3 studies	64% ± 18%	Explore
double-positive, alpha-beta thymocyte	3 studies	66% ± 17%	Explore
progenitor cell of mammary luminal epithelium	3 studies	54% ± 24%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	29% ± 9%	Explore
lung	16 studies	39% ± 14%	Explore
intestine	12 studies	37% ± 19%	Explore
kidney	8 studies	48% ± 21%	Explore
eye	8 studies	33% ± 18%	Explore
brain	7 studies	28% ± 11%	Explore
liver	7 studies	40% ± 11%	Explore
uterus	6 studies	48% ± 15%	Explore
lymph node	5 studies	53% ± 14%	Explore
prostate	4 studies	32% ± 8%	Explore
skin	4 studies	46% ± 18%	Explore
breast	4 studies	51% ± 16%	Explore
placenta	3 studies	20% ± 3%	Explore
bone marrow	3 studies	28% ± 7%	Explore
ovary	3 studies	47% ± 16%	Explore
adrenal gland	3 studies	57% ± 17%	Explore
esophagus	3 studies	54% ± 8%	Explore
pancreas	3 studies	36% ± 13%	Explore
stomach	3 studies	27% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	99%	19033.77	179 / 180	100%	82.15	430 / 430
kidney	100%	18507.08	89 / 89	99%	51.31	895 / 901
skin	99%	8950.79	1795 / 1809	100%	80.23	472 / 472
esophagus	99%	19318.48	1428 / 1445	100%	117.33	183 / 183
adrenal gland	100%	14725.91	258 / 258	98%	72.18	226 / 230
stomach	98%	11712.64	351 / 359	100%	71.29	286 / 286
breast	98%	6335.74	450 / 459	100%	79.68	1115 / 1118
prostate	98%	7912.57	240 / 245	100%	69.93	501 / 502
intestine	97%	8158.84	940 / 966	100%	88.36	525 / 527
brain	96%	16674.85	2537 / 2642	100%	72.18	704 / 705
lung	96%	28418.73	555 / 578	100%	78.16	1150 / 1155
uterus	95%	9788.31	162 / 170	100%	103.25	459 / 459
bladder	95%	13959.52	20 / 21	100%	77.05	503 / 504
liver	95%	11900.15	215 / 226	97%	43.68	395 / 406
thymus	88%	10605.17	577 / 653	99%	48.87	599 / 605
pancreas	42%	3471.25	138 / 328	99%	82.64	176 / 178
lymph node	0%	0	0 / 0	100%	36.87	29 / 29
tonsil	0%	0	0 / 0	100%	138.32	45 / 45
ureter	0%	0	0 / 0	100%	20.10	1 / 1
eye	0%	0	0 / 0	98%	37.34	78 / 80
adipose	96%	12184.45	1158 / 1204	0%	0	0 / 0
peripheral blood	92%	31707.08	854 / 929	0%	0	0 / 0
blood vessel	88%	7668.06	1181 / 1335	0%	0	0 / 0
spleen	83%	10278.61	201 / 241	0%	0	0 / 0
heart	69%	9632.46	596 / 861	0%	0	0 / 0
muscle	16%	869.46	130 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0090084	Biological process	negative regulation of inclusion body assembly
GO_0006986	Biological process	response to unfolded protein
GO_0034605	Biological process	cellular response to heat
GO_0032781	Biological process	positive regulation of ATP-dependent activity
GO_0030900	Biological process	forebrain development
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_1900034	Biological process	regulation of cellular response to heat
GO_0051085	Biological process	chaperone cofactor-dependent protein refolding
GO_0098978	Cellular component	glutamatergic synapse
GO_0005730	Cellular component	nucleolus
GO_0061827	Cellular component	sperm head
GO_0043197	Cellular component	dendritic spine
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0043025	Cellular component	neuronal cell body
GO_0005829	Cellular component	cytosol
GO_0014069	Cellular component	postsynaptic density
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0044183	Molecular function	protein folding chaperone
GO_0045296	Molecular function	cadherin binding
GO_0140416	Molecular function	transcription regulator inhibitor activity
GO_0003714	Molecular function	transcription corepressor activity
GO_0051082	Molecular function	unfolded protein binding
GO_0051087	Molecular function	protein-folding chaperone binding
GO_0030544	Molecular function	Hsp70 protein binding
GO_0051117	Molecular function	ATPase binding
GO_0005515	Molecular function	protein binding
GO_0001671	Molecular function	ATPase activator activity

IV. Literature review

[source]

Gene name	DNAJB1
Protein name	DnaJ homolog subfamily B member 1 (DnaJ protein homolog 1) (Heat shock 40 kDa protein 1) (HSP40) (Heat shock protein 40) (Human DnaJ protein 1) (hDj-1) DnaJ heat shock protein family (Hsp40) member B1 DNAJB1 protein DNAJB1 protein (DnaJ (Hsp40) homolog, subfamily B, member 1, isoform CRA_a) (cDNA, FLJ93008, Homo sapiens DnaJ (Hsp40) homolog, subfamily B, member 1 (DNAJB1),mRNA) DnaJ homolog subfamily B member 1
Synonyms	DNAJ1 HSPF1 HDJ1 hCG_1776318
Description	FUNCTION: Interacts with HSP70 and can stimulate its ATPase activity. Stimulates the association between HSC70 and HIP. Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response . Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) . .
Accessions	Q6FI51 A0A7I2V3K7 ENST00000601533 ENST00000676515.1 [P25685-2] ENST00000594099 ENST00000254322.3 [P25685-1] ENST00000595992.6 [P25685-2] M0QZD0 ENST00000678338.1 ENST00000598692 Q6FHS4 ENST00000679223.1 [P25685-2] ENST00000598692.2 [P25685-2] ENST00000596853.6 [P25685-2] ENST00000678009.1 [P25685-2] ENST00000396969.8 [P25685-2] M0QYT3 ENST00000678098.1 [P25685-2] A0A7I2YQW1 M0R1D6 ENST00000601533.6 [P25685-2] ENST00000595992 ENST00000598235.2 [P25685-2] ENST00000594099.6 [P25685-2] M0R080 A0A1B0GX60 ENST00000595139.2 ENST00000596075 ENST00000596075.2 [P25685-2] ENST00000677204.1 [P25685-2] M0QXK0 ENST00000596853 ENST00000676982.1 [P25685-2] P25685 ENST00000677762.1 [P25685-2] ENST00000676577.1 ENST00000677848.1 M0R128 ENST00000598235

DNAJB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review