HIRA report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of HIRA at tissue level.

III. Associated gene sets

GO_0042692Biological processmuscle cell differentiation
GO_0001649Biological processosteoblast differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007369Biological processgastrulation
GO_0006338Biological processchromatin remodeling
GO_0006334Biological processnucleosome assembly
GO_0006351Biological processDNA-templated transcription
GO_0009653Biological processanatomical structure morphogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0000417Cellular componentHIR complex
GO_0016605Cellular componentPML body
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042393Molecular functionhistone binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0031491Molecular functionnucleosome binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHIRA
Protein nameHistone cell cycle regulator
Protein HIRA (TUP1-like enhancer of split protein 1)
SynonymsTUPLE1
HIR
DGCR1
DescriptionFUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. .

AccessionsH7C2A7
ENST00000263208.5 [P54198-1]
ENST00000340170.8 [P54198-2]
ENST00000452818.1
P54198