LCOR report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071392Biological processcellular response to estradiol stimulus
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042826Molecular functionhistone deacetylase binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0001222Molecular functiontranscription corepressor binding
GO_0005515Molecular functionprotein binding
GO_1990226Molecular functionhistone methyltransferase binding
GO_1990381Molecular functionubiquitin-specific protease binding
GO_0030331Molecular functionnuclear estrogen receptor binding

IV. Literature review

[source]
Gene nameLCOR
Protein nameLCOR protein
Ligand-dependent corepressor (LCoR) (Mblk1-related protein 2)
Ligand dependent nuclear receptor corepressor
SynonymsMLR2
KIAA1795
C10orf12
DescriptionFUNCTION: May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand-dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. .

AccessionsA0A6Q8PGV7
ENST00000674725.1
A0A6Q8PFV7
Q96JN0
ENST00000674796.1
A0A6Q8PGL8
A0A6Q8PGR8
ENST00000676314.1
A0A6Q8PFF1
A0A6Q8PGP3
ENST00000676123.1
ENST00000675151.1
ENST00000421806.4 [Q96JN0-3]
A0A6Q8PGQ5
ENST00000675251.1
A0A6Q8PFM6
ENST00000675902.1
ENST00000676414.1
ENST00000676381.1
A0A6Q8PH28
A0A6Q8PG71
ENST00000675471.1 [Q96JN0-1]
ENST00000371097.8 [Q96JN0-1]
A0A6Q8PG56
ENST00000675915.1
ENST00000675125.1
ENST00000676187.1
A0A6Q8PGD6
ENST00000371103.8 [Q96JN0-1]
ENST00000675537.1 [Q96JN0-1]
A0A6Q8PHQ4
ENST00000676257.1
ENST00000675117.1
A0A6Q8PFQ9
ENST00000675250.1
ENST00000676067.1
A0A6Q8PFM9
ENST00000540664.6 [Q96JN0-2]
ENST00000675971.1 [Q96JN0-1]
ENST00000356016.7 [Q96JN0-1]
A0A6Q8PG83
A2VCT1
ENST00000675687.1