GPS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007254Biological processJNK cascade
GO_1900045Biological processnegative regulation of protein K63-linked ubiquitination
GO_0050859Biological processnegative regulation of B cell receptor signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0035360Biological processpositive regulation of peroxisome proliferator activated receptor signaling pathway
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0019216Biological processregulation of lipid metabolic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0050728Biological processnegative regulation of inflammatory response
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_0046329Biological processnegative regulation of JNK cascade
GO_0034122Biological processnegative regulation of toll-like receptor signaling pathway
GO_0045598Biological processregulation of fat cell differentiation
GO_0010804Biological processnegative regulation of tumor necrosis factor-mediated signaling pathway
GO_0030183Biological processB cell differentiation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0098780Biological processresponse to mitochondrial depolarisation
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0005829Cellular componentcytosol
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0005095Molecular functionGTPase inhibitor activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0003712Molecular functiontranscription coregulator activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0030332Molecular functioncyclin binding

IV. Literature review

[source]
Gene nameGPS2
Protein nameGPS2 protein
G protein pathway suppressor 2
G protein pathway suppressor 2 (GPS-2)
Synonyms
DescriptionFUNCTION: Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context . Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux by acting as a transcription coactivator . Acts as a regulator of B-cell development by inhibiting UBE2N/Ubc13, thereby restricting the activation of Toll-like receptors (TLRs) and B-cell antigen receptors (BCRs) signaling pathways (By similarity). Acts as a key mediator of mitochondrial stress response: in response to mitochondrial depolarization, relocates from the mitochondria to the nucleus following desumoylation and specifically promotes expression of nuclear-encoded mitochondrial genes . Promotes transcription of nuclear-encoded mitochondrial genes by inhibiting UBE2N/Ubc13 . Can also act as a corepressor as part of the N-Cor repressor complex by repressing active PPARG . Plays an anti-inflammatory role in macrophages and is required for insulin sensitivity by acting as a corepressor (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by interacting with sumoylated NR1H2 and NR5A2 proteins, thereby preventing N-Cor corepressor complex dissociation . In the cytosol, also plays a non-transcriptional role by regulating insulin signaling and pro-inflammatory pathways (By similarity). In the cytoplasm, acts as a negative regulator of inflammation by inhibiting the pro-inflammatory TNF-alpha pathway; acts by repressing UBE2N/Ubc13 activity (By similarity). In the cytoplasm of adipocytes, restricts the activation of insulin signaling via inhibition of UBE2N/Ubc13-mediated ubiquitination of AKT (By similarity). Able to suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction . Acts as a tumor-suppressor in liposarcoma . .; FUNCTION: (Microbial infection) Required for efficient replication of hepatitis C virus (HCV) by promoting the interaction between VAPA and HCV virus protein NS5A. .

AccessionsENST00000673265.1 [Q13227-1]
ENST00000574458.1
I3L3Y9
ENST00000570780.5
ENST00000573684.5
I3L242
ENST00000577040.2
ENST00000672046.1 [Q13227-1]
I3L4X7
Q3SY98
ENST00000380728.7 [Q13227-1]
Q13227
I3L1H4
ENST00000389167.9 [Q13227-1]