SMAD7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SMAD7 at tissue level.

III. Associated gene sets

GO_0030279Biological processnegative regulation of ossification
GO_0048844Biological processartery morphogenesis
GO_0001657Biological processureteric bud development
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_2000317Biological processnegative regulation of T-helper 17 type immune response
GO_0034333Biological processadherens junction assembly
GO_0002725Biological processnegative regulation of T cell cytokine production
GO_0060392Biological processnegative regulation of SMAD protein signal transduction
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0010944Biological processnegative regulation of transcription by competitive promoter binding
GO_0030514Biological processnegative regulation of BMP signaling pathway
GO_0060373Biological processregulation of ventricular cardiac muscle cell membrane depolarization
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0032926Biological processnegative regulation of activin receptor signaling pathway
GO_1903043Biological processpositive regulation of chondrocyte hypertrophy
GO_0055010Biological processventricular cardiac muscle tissue morphogenesis
GO_0010801Biological processnegative regulation of peptidyl-threonine phosphorylation
GO_0060395Biological processSMAD protein signal transduction
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_2000320Biological processnegative regulation of T-helper 17 cell differentiation
GO_0010719Biological processnegative regulation of epithelial to mesenchymal transition
GO_0030154Biological processcell differentiation
GO_0050821Biological processprotein stabilization
GO_0060412Biological processventricular septum morphogenesis
GO_0009653Biological processanatomical structure morphogenesis
GO_1902731Biological processnegative regulation of chondrocyte proliferation
GO_0030336Biological processnegative regulation of cell migration
GO_0033137Biological processnegative regulation of peptidyl-serine phosphorylation
GO_0034616Biological processresponse to laminar fluid shear stress
GO_0010717Biological processregulation of epithelial to mesenchymal transition
GO_0051444Biological processnegative regulation of ubiquitin-protein transferase activity
GO_0007179Biological processtransforming growth factor beta receptor signaling pathway
GO_0055117Biological processregulation of cardiac muscle contraction
GO_0031503Biological processprotein-containing complex localization
GO_0022409Biological processpositive regulation of cell-cell adhesion
GO_0005886Cellular componentplasma membrane
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0005829Cellular componentcytosol
GO_0005912Cellular componentadherens junction
GO_0005737Cellular componentcytoplasm
GO_0071144Cellular componentheteromeric SMAD protein complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990756Molecular functionubiquitin-like ligase-substrate adaptor activity
GO_0070697Molecular functionactivin receptor binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0008013Molecular functionbeta-catenin binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0034713Molecular functiontype I transforming growth factor beta receptor binding
GO_0046872Molecular functionmetal ion binding
GO_0070411Molecular functionI-SMAD binding
GO_0005518Molecular functioncollagen binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMAD7
Protein nameSMAD family member 7
Mothers against decapentaplegic homolog 7 (MAD homolog 7) (Mothers against DPP homolog 7) (Mothers against decapentaplegic homolog 8) (MAD homolog 8) (Mothers against DPP homolog 8) (SMAD family member 7) (SMAD 7) (Smad7) (hSMAD7)
SynonymsMADH7
MADH8
DescriptionFUNCTION: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access . Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. .

AccessionsENST00000589634.1 [O15105-3]
ENST00000586093.1
ENST00000262158.8 [O15105-1]
O15105
ENST00000591805.5 [O15105-2]
K7EKF0