CCND1 | OmnibusX

Name	Number of supported studies	Average coverage
pericyte	18 studies	34% ± 14%	Explore
endothelial cell	17 studies	38% ± 18%	Explore
basal cell	17 studies	37% ± 13%	Explore
smooth muscle cell	16 studies	29% ± 10%	Explore
epithelial cell	16 studies	36% ± 18%	Explore
fibroblast	16 studies	25% ± 10%	Explore
endothelial cell of lymphatic vessel	14 studies	42% ± 11%	Explore
secretory cell	11 studies	39% ± 12%	Explore
capillary endothelial cell	11 studies	34% ± 16%	Explore
ciliated cell	11 studies	32% ± 14%	Explore
club cell	9 studies	30% ± 11%	Explore
type I pneumocyte	8 studies	39% ± 16%	Explore
connective tissue cell	8 studies	25% ± 5%	Explore
oligodendrocyte precursor cell	7 studies	33% ± 8%	Explore
type II pneumocyte	6 studies	26% ± 8%	Explore
respiratory goblet cell	6 studies	29% ± 13%	Explore
kidney loop of Henle epithelial cell	5 studies	23% ± 2%	Explore
abnormal cell	5 studies	44% ± 10%	Explore
conventional dendritic cell	5 studies	24% ± 4%	Explore
macrophage	4 studies	23% ± 8%	Explore
glomerular endothelial cell	4 studies	49% ± 15%	Explore
myofibroblast cell	4 studies	44% ± 11%	Explore
endothelial cell of artery	4 studies	21% ± 6%	Explore
brush cell	4 studies	29% ± 13%	Explore
microglial cell	4 studies	30% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	30% ± 11%	Explore
keratinocyte	4 studies	34% ± 16%	Explore
duct epithelial cell	3 studies	25% ± 2%	Explore
hillock cell	3 studies	30% ± 13%	Explore
neural crest cell	3 studies	34% ± 10%	Explore
vein endothelial cell	3 studies	30% ± 18%	Explore
hepatocyte	3 studies	45% ± 25%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	8 studies	29% ± 10%	Explore
intestine	4 studies	22% ± 5%	Explore
kidney	3 studies	27% ± 9%	Explore
uterus	3 studies	30% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	6879.54	245 / 245	97%	133.86	488 / 502
skin	100%	13738.38	1806 / 1809	95%	326.22	449 / 472
esophagus	99%	6461.35	1436 / 1445	94%	320.96	172 / 183
thymus	99%	4715.93	647 / 653	93%	270.09	560 / 605
breast	98%	6945.68	451 / 459	91%	398.67	1013 / 1118
pancreas	97%	2810.38	318 / 328	88%	120.52	156 / 178
lung	99%	5972.50	570 / 578	85%	174.64	984 / 1155
intestine	88%	2417.24	854 / 966	95%	142.44	499 / 527
bladder	95%	2807.14	20 / 21	82%	160.87	415 / 504
stomach	82%	2590.06	294 / 359	93%	150.84	265 / 286
kidney	88%	3105.38	78 / 89	82%	336.20	742 / 901
adrenal gland	98%	3539.08	254 / 258	66%	79.30	152 / 230
liver	96%	4729.73	216 / 226	51%	76.13	206 / 406
brain	64%	1425.82	1686 / 2642	56%	62.11	397 / 705
uterus	65%	1901.72	110 / 170	45%	59.42	208 / 459
ureter	0%	0	0 / 0	100%	419.41	1 / 1
blood vessel	100%	6694.72	1329 / 1335	0%	0	0 / 0
heart	98%	4156.02	846 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	98%	223.23	78 / 80
adipose	95%	6226.79	1148 / 1204	0%	0	0 / 0
spleen	82%	2161.55	198 / 241	0%	0	0 / 0
ovary	18%	321.49	33 / 180	63%	90.58	269 / 430
tonsil	0%	0	0 / 0	47%	65.20	21 / 45
lymph node	0%	0	0 / 0	7%	3.73	2 / 29
peripheral blood	5%	91.17	43 / 929	0%	0	0 / 0
muscle	1%	13.83	7 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0010971	Biological process	positive regulation of G2/M transition of mitotic cell cycle
GO_0044321	Biological process	response to leptin
GO_0045444	Biological process	fat cell differentiation
GO_0070141	Biological process	response to UV-A
GO_0033598	Biological process	mammary gland epithelial cell proliferation
GO_0000079	Biological process	regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0006974	Biological process	DNA damage response
GO_0045737	Biological process	positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO_0051301	Biological process	cell division
GO_0001934	Biological process	positive regulation of protein phosphorylation
GO_0000122	Biological process	negative regulation of transcription by RNA polymerase II
GO_0060749	Biological process	mammary gland alveolus development
GO_1900087	Biological process	positive regulation of G1/S transition of mitotic cell cycle
GO_0030968	Biological process	endoplasmic reticulum unfolded protein response
GO_0030857	Biological process	negative regulation of epithelial cell differentiation
GO_0030182	Biological process	neuron differentiation
GO_0097421	Biological process	liver regeneration
GO_0033601	Biological process	positive regulation of mammary gland epithelial cell proliferation
GO_0007595	Biological process	lactation
GO_0016055	Biological process	Wnt signaling pathway
GO_0031571	Biological process	mitotic G1 DNA damage checkpoint signaling
GO_0009410	Biological process	response to xenobiotic stimulus
GO_0043524	Biological process	negative regulation of neuron apoptotic process
GO_0000320	Biological process	re-entry into mitotic cell cycle
GO_0000082	Biological process	G1/S transition of mitotic cell cycle
GO_0097131	Cellular component	cyclin D1-CDK6 complex
GO_0097128	Cellular component	cyclin D1-CDK4 complex
GO_0005813	Cellular component	centrosome
GO_0005654	Cellular component	nucleoplasm
GO_0017053	Cellular component	transcription repressor complex
GO_0000307	Cellular component	cyclin-dependent protein kinase holoenzyme complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005923	Cellular component	bicellular tight junction
GO_0031965	Cellular component	nuclear membrane
GO_0005634	Cellular component	nucleus
GO_0019899	Molecular function	enzyme binding
GO_0061575	Molecular function	cyclin-dependent protein serine/threonine kinase activator activity
GO_0070064	Molecular function	proline-rich region binding
GO_0019901	Molecular function	protein kinase binding
GO_0003714	Molecular function	transcription corepressor activity
GO_0016538	Molecular function	cyclin-dependent protein serine/threonine kinase regulator activity
GO_0004672	Molecular function	protein kinase activity
GO_0005515	Molecular function	protein binding
GO_0042826	Molecular function	histone deacetylase binding

IV. Literature review

[source]

Gene name	CCND1
Protein name	Cyclin D1 G1/S-specific cyclin-D1 G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein) (BCL-1) (BCL-1 oncogene) (PRAD1 oncogene)
Synonyms	hCG_2016647 PRAD1 BCL1
Description	FUNCTION: Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition . Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase . Hypophosphorylates RB1 in early G(1) phase . Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals . Also a substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity . Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex . Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner . .
Accessions	P24385 ENST00000536559.1 Q6FI00 F5H437 Q5MGB2 ENST00000227507.3

CCND1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review