TRIM28 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0045869Biological processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0016925Biological processprotein sumoylation
GO_0001837Biological processepithelial to mesenchymal transition
GO_0006281Biological processDNA repair
GO_0060028Biological processconvergent extension involved in axis elongation
GO_0045087Biological processinnate immune response
GO_0045739Biological processpositive regulation of DNA repair
GO_0060669Biological processembryonic placenta morphogenesis
GO_0090309Biological processpositive regulation of DNA methylation-dependent heterochromatin formation
GO_0042307Biological processpositive regulation of protein import into nucleus
GO_0071514Biological processgenomic imprinting
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0044790Biological processsuppression of viral release by host
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0007566Biological processembryo implantation
GO_0000792Cellular componentheterochromatin
GO_0000791Cellular componenteuchromatin
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0019789Molecular functionSUMO transferase activity
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0003682Molecular functionchromatin binding
GO_0070087Molecular functionchromo shadow domain binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0004672Molecular functionprotein kinase activity
GO_0035851Molecular functionKrueppel-associated box domain binding
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM28
Protein nameTranscription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Tripartite motif containing 28
SynonymsTIF1B
RNF96
KAP1
DescriptionFUNCTION: Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also a corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger. Also specifically sumoylates IRF7, thereby inhibiting its transactivation activity. Ubiquitinates p53/TP53 leading to its proteasomal degradation; the function is enhanced by MAGEC2 and MAGEA2, and possibly MAGEA3 and MAGEA6. Mediates the nuclear localization of KOX1, ZNF268 and ZNF300 transcription factors. In association with isoform 2 of ZFP90, is required for the transcriptional repressor activity of FOXP3 and the suppressive function of regulatory T-cells (Treg) . Probably forms a corepressor complex required for activated KRAS-mediated promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes in colorectal cancer (CRC) cells . Required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs) . In ESCs, in collaboration with SETDB1, is also required for H3K9me3 and silencing of endogenous and introduced retroviruses in a DNA-methylation independent-pathway (By similarity). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their gene silencing . The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions . .; FUNCTION: (Microbial infection) Plays a critical role in the shutdown of lytic gene expression during the early stage of herpes virus 8 primary infection. This inhibition is mediated through interaction with herpes virus 8 protein LANA1. .

AccessionsENST00000597968.1
ENST00000341753.10 [Q13263-2]
ENST00000597136.1
M0R0K9
M0R2I3
ENST00000593582.5
M0R3C0
ENST00000253024.10 [Q13263-1]
Q13263
ENST00000594806.5
M0QZE6