SDR16C5 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SDR16C5 at tissue level.

III. Associated gene sets

GO_0045814Biological processnegative regulation of gene expression, epigenetic
GO_0042574Biological processretinal metabolic process
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043616Biological processkeratinocyte proliferation
GO_0042572Biological processretinol metabolic process
GO_0005783Cellular componentendoplasmic reticulum
GO_0017053Cellular componenttranscription repressor complex
GO_0000785Cellular componentchromatin
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005634Cellular componentnucleus
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0004745Molecular functionall-trans-retinol dehydrogenase (NAD+) activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSDR16C5
Protein nameEpidermal retinol dehydrogenase 2 (EPHD-2) (RDH-E2) (EC 1.1.1.105) (Retinal short-chain dehydrogenase reductase 2) (retSDR2) (Short-chain dehydrogenase/reductase family 16C member 5)
Retinal short chain dehydrogenase reductase isoform 1, isoform CRA_c (Short chain dehydrogenase/reductase family 16C member 5)
SynonymshCG_1787435
RDHE2
DescriptionFUNCTION: Oxidoreductase with strong preference for NAD . Active in both the oxidative and reductive directions . Oxidizes all-trans-retinol in all-trans-retinaldehyde . No activity was detected with 11-cis-retinol or 11-cis-retinaldehyde as substrates with either NAD(+)/NADH or NADP(+)/NADPH . .

AccessionsQ8N3Y7
ENST00000522671.1
ENST00000396721.6 [Q8N3Y7-2]
G3V145
ENST00000303749.8 [Q8N3Y7-1]