LMCD1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LMCD1 at tissue level.

III. Associated gene sets

GO_0070886Biological processpositive regulation of calcineurin-NFAT signaling cascade
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010611Biological processregulation of cardiac muscle hypertrophy
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameLMCD1
Protein nameLIM and cysteine-rich domains protein 1 (Dyxin)
LIM and cysteine rich domains 1
LIM and cysteine rich domains 1 (cDNA FLJ52480, highly similar to LIM and cysteine-rich domains protein 1)
Synonyms
DescriptionFUNCTION: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity). Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway. .

AccessionsENST00000157600.8 [Q9NZU5-1]
ENST00000397386.7
ENST00000415597.5
C9IYS1
ENST00000456506.2
ENST00000426878.2
ENST00000454244.4 [Q9NZU5-2]
H7C3D2
F8WB09
Q9NZU5
B4DEY6