SFMBT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0048635Biological processnegative regulation of muscle organ development
GO_0007283Biological processspermatogenesis
GO_0030154Biological processcell differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding

IV. Literature review

[source]
Gene nameSFMBT1
Protein nameScm like with four mbt domains 1
Scm-like with four MBT domains protein 1 (hSFMBT) (Renal ubiquitous protein 1)
SynonymsRU1
DescriptionFUNCTION: Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis. .

AccessionsC9IY64
ENST00000483069.5
C9JWI3
ENST00000497586.5
C9IZZ5
ENST00000482396.5
ENST00000394752.8 [Q9UHJ3-1]
Q9UHJ3