NR0B1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of NR0B1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of NR0B1 at tissue level.

III. Associated gene sets

GO_0010894Biological processnegative regulation of steroid biosynthetic process
GO_0008406Biological processgonad development
GO_0007283Biological processspermatogenesis
GO_0030238Biological processmale sex determination
GO_0035902Biological processresponse to immobilization stress
GO_0035987Biological processendodermal cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0060008Biological processSertoli cell differentiation
GO_0030325Biological processadrenal gland development
GO_0008584Biological processmale gonad development
GO_0008104Biological processprotein localization
GO_0021983Biological processpituitary gland development
GO_0033327Biological processLeydig cell differentiation
GO_0021854Biological processhypothalamus development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0033144Biological processnegative regulation of intracellular steroid hormone receptor signaling pathway
GO_0034451Cellular componentcentriolar satellite
GO_0005840Cellular componentribosome
GO_0016020Cellular componentmembrane
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0016922Molecular functionnuclear receptor binding
GO_0019904Molecular functionprotein domain specific binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0032448Molecular functionDNA hairpin binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNR0B1
Protein nameNuclear receptor subfamily 0 group B member 1 (DSS-AHC critical region on the X chromosome protein 1) (Nuclear receptor DAX-1)
Truncated nuclear receptor subfamily 0 group B member 1
Nuclear receptor subfamily 0 group B member 1 (Nuclear receptor DAX-1)
Nuclear receptor subfamily 0 group B member 1
SynonymshCG_15520
AHC
DAX1
DescriptionFUNCTION: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency (By similarity). .

FUNCTION: Orphan nuclear receptor. Component of a cascade required for the development of the hypothalamic-pituitary-adrenal-gonadal axis. Acts as a coregulatory protein that inhibits the transcriptional activity of other nuclear receptors through heterodimeric interactions. May also have a role in the development of the embryo and in the maintenance of embryonic stem cell pluripotency. .

AccessionsENST00000378963.1
F1D8P4
A0A218PFR0
A6NNU8
ENST00000378970.5 [P51843-1]
P51843