HDAC7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007043Biological processcell-cell junction assembly
GO_0016925Biological processprotein sumoylation
GO_0032703Biological processnegative regulation of interleukin-2 production
GO_0050684Biological processregulation of mRNA processing
GO_0006476Biological processprotein deacetylation
GO_0001570Biological processvasculogenesis
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_1901223Biological processnegative regulation of non-canonical NF-kappaB signal transduction
GO_0090050Biological processpositive regulation of cell migration involved in sprouting angiogenesis
GO_0045668Biological processnegative regulation of osteoblast differentiation
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0033558Molecular functionprotein lysine deacetylase activity
GO_0019789Molecular functionSUMO transferase activity
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0003682Molecular functionchromatin binding
GO_0004407Molecular functionhistone deacetylase activity
GO_0019901Molecular functionprotein kinase binding
GO_0071889Molecular function14-3-3 protein binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameHDAC7
Protein nameHistone deacetylase 7 (HD7) (EC 3.5.1.98) (Histone deacetylase 7A) (HD7a)
Histone deacetylase (EC 3.5.1.98)
histone deacetylase (EC 3.5.1.98)
Histone deacetylase 7
SynonymsHDAC7A
DescriptionFUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 . Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding . In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response . .

FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. .

AccessionsENST00000552960.5 [Q8WUI4-6]
C9J102
C9JZ79
ENST00000488927.2
ENST00000440293.5
ENST00000447463.5
ENST00000548080.5
H0YI15
ENST00000427332.6 [Q8WUI4-1]
ENST00000445237.2
ENST00000417902.5
C9JNI4
ENST00000548938.5
ENST00000450805.5
F8VWY3
C9JEB6
C9JAH2
ENST00000425451.2
A0A087WYQ4
ENST00000421231.5
C9JF80
ENST00000434070.5
C9JKN3
H0YH91
C9JVZ1
ENST00000080059.12 [Q8WUI4-5]
ENST00000433685.5
Q8WUI4
ENST00000422254.5
ENST00000417107.5
ENST00000430670.5
ENST00000477203.6
J3KPH8
C9JGF5
H0YHJ5
ENST00000485796.5
C9JH46
ENST00000354334.7 [Q8WUI4-7]
C9JBC2
ENST00000380610.8
H0YI41
ENST00000547259.1