Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 8 studies | 39% ± 14% | |
| enterocyte | 7 studies | 43% ± 15% | |
| goblet cell | 5 studies | 31% ± 8% | |
| endothelial cell | 5 studies | 21% ± 4% | |
| macrophage | 4 studies | 32% ± 18% | |
| astrocyte | 4 studies | 20% ± 5% | |
| pancreatic A cell | 3 studies | 28% ± 16% | |
| epithelial cell of proximal tubule | 3 studies | 27% ± 5% | |
| myeloid cell | 3 studies | 20% ± 6% | |
| progenitor cell | 3 studies | 23% ± 2% | |
| GABAergic neuron | 3 studies | 35% ± 6% | |
| glutamatergic neuron | 3 studies | 44% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 1959.78 | 459 / 459 | 100% | 56.86 | 1118 / 1118 |
| intestine | 100% | 5364.37 | 966 / 966 | 100% | 87.96 | 527 / 527 |
| liver | 100% | 1760.77 | 226 / 226 | 100% | 48.70 | 406 / 406 |
| ovary | 100% | 1559.13 | 180 / 180 | 100% | 39.06 | 430 / 430 |
| prostate | 100% | 3538.89 | 245 / 245 | 100% | 82.60 | 502 / 502 |
| esophagus | 100% | 1686.71 | 1444 / 1445 | 100% | 48.84 | 183 / 183 |
| brain | 100% | 2159.31 | 2638 / 2642 | 100% | 42.82 | 705 / 705 |
| thymus | 100% | 1598.03 | 653 / 653 | 100% | 45.80 | 604 / 605 |
| bladder | 100% | 2325.10 | 21 / 21 | 100% | 67.39 | 503 / 504 |
| lung | 100% | 2199.31 | 576 / 578 | 100% | 62.11 | 1155 / 1155 |
| stomach | 100% | 1626.21 | 359 / 359 | 100% | 68.16 | 285 / 286 |
| adrenal gland | 100% | 1986.91 | 258 / 258 | 100% | 43.30 | 229 / 230 |
| uterus | 100% | 1766.79 | 170 / 170 | 100% | 52.20 | 457 / 459 |
| pancreas | 99% | 1219.08 | 326 / 328 | 100% | 48.29 | 178 / 178 |
| kidney | 100% | 3123.66 | 89 / 89 | 99% | 52.97 | 891 / 901 |
| skin | 100% | 1959.10 | 1807 / 1809 | 95% | 41.01 | 448 / 472 |
| adipose | 100% | 1995.64 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 65.70 | 29 / 29 |
| spleen | 100% | 2568.41 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 44.86 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 34.72 | 1 / 1 |
| blood vessel | 100% | 2268.49 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 99% | 3977.56 | 924 / 929 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1274.62 | 793 / 803 | 0% | 0 | 0 / 0 |
| heart | 96% | 1337.70 | 824 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 83% | 24.68 | 66 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006302 | Biological process | double-strand break repair |
| GO_0048666 | Biological process | neuron development |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0007166 | Biological process | cell surface receptor signaling pathway |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0016604 | Cellular component | nuclear body |
| GO_0016605 | Cellular component | PML body |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0016235 | Cellular component | aggresome |
| GO_0005634 | Cellular component | nucleus |
| GO_0070260 | Molecular function | 5'-tyrosyl-DNA phosphodiesterase activity |
| GO_0003697 | Molecular function | single-stranded DNA binding |
| GO_0003714 | Molecular function | transcription corepressor activity |
| GO_0000287 | Molecular function | magnesium ion binding |
| GO_0030145 | Molecular function | manganese ion binding |
| GO_0004518 | Molecular function | nuclease activity |
| GO_0036317 | Molecular function | tyrosyl-RNA phosphodiesterase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | TDP2 |
| Protein name | Tyrosyl-DNA phosphodiesterase 2 (5'-tyrosyl-DNA phosphodiesterase) Tyrosyl-DNA phosphodiesterase 2 Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase) |
| Synonyms | TTRAP AD-022 hCG_37519 EAP2 |
| Description | FUNCTION: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation . Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. .; FUNCTION: (Microbial infection) Also acts as a 5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA. . |
| Accessions | O95551 X6R5A3 ENST00000378198.9 [O95551-1] ENST00000341060.3 I3QNV0 |