TDP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006302Biological processdouble-strand break repair
GO_0048666Biological processneuron development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0007166Biological processcell surface receptor signaling pathway
GO_0005730Cellular componentnucleolus
GO_0005654Cellular componentnucleoplasm
GO_0016604Cellular componentnuclear body
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0016235Cellular componentaggresome
GO_0005634Cellular componentnucleus
GO_0070260Molecular function5'-tyrosyl-DNA phosphodiesterase activity
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0000287Molecular functionmagnesium ion binding
GO_0030145Molecular functionmanganese ion binding
GO_0004518Molecular functionnuclease activity
GO_0036317Molecular functiontyrosyl-RNA phosphodiesterase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTDP2
Protein nameTyrosyl-DNA phosphodiesterase 2 (5'-tyrosyl-DNA phosphodiesterase)
Tyrosyl-DNA phosphodiesterase 2
Tyrosyl-DNA phosphodiesterase 2 (Tyr-DNA phosphodiesterase 2) (hTDP2) (EC 3.1.4.-) (5'-tyrosyl-DNA phosphodiesterase) (5'-Tyr-DNA phosphodiesterase) (ETS1-associated protein 2) (ETS1-associated protein II) (EAPII) (TRAF and TNF receptor-associated protein) (Tyrosyl-RNA phosphodiesterase) (VPg unlinkase)
SynonymsTTRAP
AD-022
hCG_37519
EAP2
DescriptionFUNCTION: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation . Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Acts as a regulator of ribosome biogenesis following stress. Has also 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. .; FUNCTION: (Microbial infection) Also acts as a 5'-tyrosyl-RNA phosphodiesterase following picornavirus infection: its activity is hijacked by picornavirus and acts by specifically cleaving the protein-RNA covalent linkage generated during the viral genomic RNA replication steps of a picornavirus infection, without impairing the integrity of viral RNA. .

AccessionsO95551
X6R5A3
ENST00000378198.9 [O95551-1]
ENST00000341060.3
I3QNV0