| Name | tyrosyl-RNA phosphodiesterase activity |
| ID | GO_0036317 |
| collection_id | Molecular function |
| Exact synonym | VPg unlinkase activity, Y-pUpN PDE activity, unlinkase activity, uridylylpolynucleotide-(5' P->O)- tyrosine phosphodiesterase activity |
| Description | Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis. |
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| Genes |