SPEN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050769Biological processpositive regulation of neurogenesis
GO_0007219Biological processNotch signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0017053Cellular componenttranscription repressor complex
GO_0005634Cellular componentnucleus
GO_0003723Molecular functionRNA binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0003677Molecular functionDNA binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0003729Molecular functionmRNA binding

IV. Literature review

[source]
Gene nameSPEN
Protein nameSpen family transcriptional repressor
Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog)
SynonymsMINT
KIAA0929
SHARP
DescriptionFUNCTION: May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA. .

AccessionsENST00000673875.1
Q96T58
ENST00000442985.1
ENST00000375759.8
H0Y5U7
ENST00000438066.2
A0A669KB49
ENST00000704274.1
A0A994J7B7
F6WRY4