TRIB3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of TRIB3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRIB3 at tissue level.

III. Associated gene sets

GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0006469Biological processnegative regulation of protein kinase activity
GO_0032869Biological processcellular response to insulin stimulus
GO_0034976Biological processresponse to endoplasmic reticulum stress
GO_0051443Biological processpositive regulation of ubiquitin-protein transferase activity
GO_0032092Biological processpositive regulation of protein binding
GO_0032436Biological processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0045599Biological processnegative regulation of fat cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010506Biological processregulation of autophagy
GO_0043405Biological processregulation of MAP kinase activity
GO_0045717Biological processnegative regulation of fatty acid biosynthetic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0010827Biological processregulation of glucose transmembrane transport
GO_0005886Cellular componentplasma membrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0004860Molecular functionprotein kinase inhibitor activity
GO_0031434Molecular functionmitogen-activated protein kinase kinase binding
GO_0019901Molecular functionprotein kinase binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0055106Molecular functionubiquitin-protein transferase regulator activity
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIB3
Protein nameTribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)
Tribbles pseudokinase 3
SynonymsSKIP3
C20orf97
TRB3
NIPK
DescriptionFUNCTION: Inactive protein kinase which acts as a regulator of the integrated stress response (ISR), a process for adaptation to various stress . Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress . May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells . Acts as a negative feedback regulator of the ATF4-dependent transcription during the ISR: while TRIB3 expression is promoted by ATF4, TRIB3 protein interacts with ATF4 and inhibits ATF4 transcription activity (By similarity). Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation (By similarity). May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1 (By similarity). Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity . Interacts with MAPK kinases and regulates activation of MAP kinases . Can inhibit APOBEC3A editing of nuclear DNA . .

AccessionsQ96RU7
A0A087WTX3
ENST00000422053.3
J3KR25
B0QYQ2
ENST00000615226.4
ENST00000449710.5
ENST00000217233.9