MTA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0010971Biological processpositive regulation of G2/M transition of mitotic cell cycle
GO_2000736Biological processregulation of stem cell differentiation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1904197Biological processpositive regulation of granulosa cell proliferation
GO_0006338Biological processchromatin remodeling
GO_0042659Biological processregulation of cell fate specification
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_1990739Biological processgranulosa cell proliferation
GO_0000086Biological processG2/M transition of mitotic cell cycle
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0016581Cellular componentNuRD complex
GO_0005634Cellular componentnucleus
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003682Molecular functionchromatin binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0046872Molecular functionmetal ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameMTA3
Protein nameMetastasis associated 1 family member 3
Metastasis-associated protein MTA3
Metastasis associated 1 family member 3 (Metastasis associated 1 family, member 3, isoform CRA_a)
SynonymsKIAA1266
hCG_1783907
DescriptionFUNCTION: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin . Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels . Contributes to transcriptional repression by BCL6 . .

AccessionsC9JR73
ENST00000405094.2 [Q9BTC8-1]
E9PCS8
ENST00000454356.5
F6RRE2
ENST00000409019.5
ENST00000406652.5
ENST00000407270.7 [Q9BTC8-2]
ENST00000405592.5
ENST00000430763.5
ENST00000406911.5
ENST00000433553.5
E7EV10
E9PF88
Q9BTC8
E7EQY4