DNMT3A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0046500Biological processS-adenosylmethionine metabolic process
GO_0032355Biological processresponse to estradiol
GO_0007283Biological processspermatogenesis
GO_0032259Biological processmethylation
GO_0010212Biological processresponse to ionizing radiation
GO_0071361Biological processcellular response to ethanol
GO_0141068Biological processautosome genomic imprinting
GO_1900039Biological processpositive regulation of cellular response to hypoxia
GO_0006346Biological processDNA methylation-dependent heterochromatin formation
GO_1903926Biological processcellular response to bisphenol A
GO_0031048Biological processregulatory ncRNA-mediated heterochromatin formation
GO_0010288Biological processresponse to lead ion
GO_0044027Biological processnegative regulation of gene expression via chromosomal CpG island methylation
GO_0033189Biological processresponse to vitamin A
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0030182Biological processneuron differentiation
GO_0042220Biological processresponse to cocaine
GO_0097284Biological processhepatocyte apoptotic process
GO_0071230Biological processcellular response to amino acid stimulus
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0009636Biological processresponse to toxic substance
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0071456Biological processcellular response to hypoxia
GO_0000775Cellular componentchromosome, centromeric region
GO_1902494Cellular componentcatalytic complex
GO_0000792Cellular componentheterochromatin
GO_0000791Cellular componenteuchromatin
GO_0005654Cellular componentnucleoplasm
GO_0016363Cellular componentnuclear matrix
GO_0005737Cellular componentcytoplasm
GO_0001741Cellular componentXY body
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003886Molecular functionDNA (cytosine-5-)-methyltransferase activity
GO_0003682Molecular functionchromatin binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0042802Molecular functionidentical protein binding
GO_0106363Molecular functionprotein-cysteine methyltransferase activity
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0106222Molecular functionlncRNA binding
GO_0046872Molecular functionmetal ion binding
GO_0045322Molecular functionunmethylated CpG binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameDNMT3A
Protein nameDNMT3A protein
DNA methyltransferase 3 alpha
DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37)
DNA (cytosine-5)-methyltransferase 3A (Dnmt3a) (EC 2.1.1.37) (Cysteine methyltransferase DNMT3A) (EC 2.1.1.-) (DNA methyltransferase HsaIIIA) (DNA MTase HsaIIIA) (M.HsaIIIA)
Synonyms
DescriptionFUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development . DNA methylation is coordinated with methylation of histones . It modifies DNA in a non-processive manner and also methylates non-CpG sites . May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1 (By similarity). Plays a role in paternal and maternal imprinting (By similarity). Required for methylation of most imprinted loci in germ cells (By similarity). Acts as a transcriptional corepressor for ZBTB18 (By similarity). Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites (By similarity). Can actively repress transcription through the recruitment of HDAC activity (By similarity). Also has weak auto-methylation activity on Cys-710 in absence of DNA (By similarity). .

AccessionsA0A8I5KXG9
ENST00000264709.7 [Q9Y6K1-1]
ENST00000470983.5
F8WE91
Q9Y6K1
A0A8I5KPS0
ENST00000402667.1
Q6PJ37
ENST00000380746.8 [Q9Y6K1-2]
ENST00000482935.5
A0A8I5QKW3
ENST00000461228.1
ENST00000683393.1
ENST00000406659.3 [Q9Y6K1-3]
ENST00000491288.5
ENST00000683760.1
ENST00000321117.10 [Q9Y6K1-1]
ENST00000380756.7
A0A8I5KNQ0
A0A8I5KUD4
ENST00000474887.6
A0A0C4DG02
Q8WVA9
A0A8I5KTF6