SETD5 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	34 studies	38% ± 19%	Explore
fibroblast	28 studies	32% ± 15%	Explore
pericyte	23 studies	30% ± 16%	Explore
astrocyte	19 studies	47% ± 19%	Explore
smooth muscle cell	17 studies	28% ± 12%	Explore
oligodendrocyte precursor cell	16 studies	56% ± 21%	Explore
oligodendrocyte	14 studies	38% ± 16%	Explore
microglial cell	14 studies	44% ± 15%	Explore
ciliated cell	13 studies	31% ± 12%	Explore
macrophage	13 studies	36% ± 18%	Explore
mast cell	13 studies	28% ± 9%	Explore
basal cell	12 studies	34% ± 19%	Explore
glutamatergic neuron	12 studies	53% ± 25%	Explore
B cell	12 studies	24% ± 7%	Explore
capillary endothelial cell	12 studies	21% ± 7%	Explore
epithelial cell	12 studies	38% ± 21%	Explore
GABAergic neuron	11 studies	52% ± 23%	Explore
natural killer cell	10 studies	22% ± 6%	Explore
endothelial cell of lymphatic vessel	10 studies	36% ± 16%	Explore
adipocyte	10 studies	50% ± 11%	Explore
T cell	9 studies	25% ± 8%	Explore
endothelial cell of artery	8 studies	20% ± 4%	Explore
myofibroblast cell	8 studies	28% ± 14%	Explore
vein endothelial cell	8 studies	27% ± 17%	Explore
amacrine cell	8 studies	46% ± 16%	Explore
type I pneumocyte	8 studies	36% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	7 studies	22% ± 5%	Explore
CD4-positive, alpha-beta T cell	7 studies	20% ± 4%	Explore
neuron	7 studies	47% ± 20%	Explore
retinal ganglion cell	7 studies	53% ± 20%	Explore
connective tissue cell	7 studies	29% ± 12%	Explore
myeloid cell	7 studies	28% ± 4%	Explore
CD8-positive, alpha-beta T cell	7 studies	20% ± 4%	Explore
dendritic cell	7 studies	34% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	6 studies	20% ± 4%	Explore
interneuron	6 studies	63% ± 19%	Explore
club cell	6 studies	40% ± 14%	Explore
retina horizontal cell	6 studies	42% ± 16%	Explore
retinal cone cell	6 studies	37% ± 9%	Explore
endothelial cell of vascular tree	6 studies	31% ± 17%	Explore
type II pneumocyte	6 studies	40% ± 9%	Explore
naive B cell	6 studies	21% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	21% ± 5%	Explore
abnormal cell	5 studies	31% ± 17%	Explore
retinal bipolar neuron	5 studies	40% ± 13%	Explore
cardiac muscle cell	5 studies	38% ± 7%	Explore
mesothelial cell	5 studies	34% ± 10%	Explore
lymphocyte	5 studies	32% ± 13%	Explore
Mueller cell	5 studies	44% ± 14%	Explore
respiratory goblet cell	5 studies	41% ± 15%	Explore
monocyte	5 studies	32% ± 7%	Explore
goblet cell	5 studies	38% ± 27%	Explore
CD8-positive, alpha-beta memory T cell	5 studies	19% ± 3%	Explore
regulatory T cell	5 studies	19% ± 3%	Explore
plasmacytoid dendritic cell	5 studies	22% ± 6%	Explore
secretory cell	4 studies	27% ± 2%	Explore
classical monocyte	4 studies	22% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	4 studies	20% ± 5%	Explore
glial cell	4 studies	37% ± 14%	Explore
granule cell	4 studies	50% ± 4%	Explore
progenitor cell	4 studies	34% ± 9%	Explore
mucosal invariant T cell	4 studies	22% ± 4%	Explore
plasma cell	4 studies	37% ± 7%	Explore
retinal pigment epithelial cell	4 studies	41% ± 27%	Explore
OFF-bipolar cell	4 studies	40% ± 13%	Explore
ON-bipolar cell	4 studies	47% ± 15%	Explore
retinal rod cell	4 studies	44% ± 7%	Explore
muscle cell	4 studies	40% ± 26%	Explore
enteroendocrine cell	4 studies	25% ± 8%	Explore
leukocyte	4 studies	37% ± 13%	Explore
gamma-delta T cell	4 studies	23% ± 10%	Explore
memory B cell	4 studies	18% ± 3%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	19% ± 0%	Explore
hematopoietic precursor cell	3 studies	30% ± 11%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	54% ± 8%	Explore
neural crest cell	3 studies	20% ± 1%	Explore
GABAergic interneuron	3 studies	51% ± 4%	Explore
pro-B cell	3 studies	24% ± 2%	Explore
squamous epithelial cell	3 studies	35% ± 22%	Explore
mononuclear phagocyte	3 studies	30% ± 7%	Explore
GABAergic amacrine cell	3 studies	56% ± 10%	Explore
glycinergic amacrine cell	3 studies	53% ± 8%	Explore
rod bipolar cell	3 studies	52% ± 17%	Explore
mature NK T cell	3 studies	23% ± 10%	Explore
hepatocyte	3 studies	63% ± 18%	Explore
ependymal cell	3 studies	51% ± 18%	Explore
adventitial cell	3 studies	27% ± 7%	Explore
alveolar macrophage	3 studies	39% ± 10%	Explore
chondrocyte	3 studies	38% ± 14%	Explore
group 3 innate lymphoid cell	3 studies	23% ± 5%	Explore
transit amplifying cell	3 studies	44% ± 34%	Explore
brush cell	3 studies	26% ± 5%	Explore
mural cell	3 studies	43% ± 8%	Explore
mucus secreting cell	3 studies	40% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	47% ± 22%	Explore
lung	10 studies	29% ± 9%	Explore
eye	8 studies	42% ± 19%	Explore
intestine	6 studies	20% ± 8%	Explore
heart	5 studies	34% ± 8%	Explore
liver	4 studies	36% ± 18%	Explore
adipose	4 studies	39% ± 19%	Explore
peripheral blood	3 studies	23% ± 2%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	9282.71	21 / 21	100%	30.39	504 / 504
breast	100%	9735.72	459 / 459	100%	41.79	1118 / 1118
esophagus	100%	8671.13	1445 / 1445	100%	32.62	183 / 183
lung	100%	11973.45	578 / 578	100%	29.45	1151 / 1155
intestine	100%	9473.48	966 / 966	100%	25.43	525 / 527
prostate	100%	9519.28	245 / 245	99%	28.55	499 / 502
ovary	100%	11262.97	180 / 180	99%	32.29	427 / 430
stomach	100%	6626.24	359 / 359	99%	26.01	283 / 286
uterus	100%	11597.90	170 / 170	99%	31.66	454 / 459
pancreas	100%	5324.42	328 / 328	99%	26.51	176 / 178
skin	100%	9937.44	1809 / 1809	99%	29.10	466 / 472
thymus	100%	11780.52	653 / 653	99%	30.72	597 / 605
brain	99%	6804.96	2607 / 2642	100%	56.69	704 / 705
adrenal gland	100%	9209.24	258 / 258	97%	17.50	222 / 230
kidney	100%	5468.15	89 / 89	94%	18.08	851 / 901
liver	100%	4884.81	226 / 226	83%	12.19	336 / 406
adipose	100%	8923.77	1204 / 1204	0%	0	0 / 0
muscle	100%	4999.92	803 / 803	0%	0	0 / 0
spleen	100%	8781.75	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	13.92	1 / 1
blood vessel	100%	8164.46	1334 / 1335	0%	0	0 / 0
heart	99%	5163.13	851 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	31.24	44 / 45
lymph node	0%	0	0 / 0	97%	20.53	28 / 29
peripheral blood	90%	5251.78	837 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	85%	12.19	68 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0032259	Biological process	methylation
GO_1902275	Biological process	regulation of chromatin organization
GO_0016480	Biological process	negative regulation of transcription by RNA polymerase III
GO_0032784	Biological process	regulation of DNA-templated transcription elongation
GO_0006338	Biological process	chromatin remodeling
GO_0051963	Biological process	regulation of synapse assembly
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0050890	Biological process	cognition
GO_0034967	Cellular component	Set3 complex
GO_0000791	Cellular component	euchromatin
GO_0005654	Cellular component	nucleoplasm
GO_0070210	Cellular component	Rpd3L-Expanded complex
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0035064	Molecular function	methylated histone binding
GO_0140955	Molecular function	histone H3K36 trimethyltransferase activity
GO_0046974	Molecular function	histone H3K9 methyltransferase activity
GO_0003714	Molecular function	transcription corepressor activity
GO_0140947	Molecular function	histone H3K9me2 methyltransferase activity
GO_0046975	Molecular function	histone H3K36 methyltransferase activity
GO_0140948	Molecular function	histone H3K9 monomethyltransferase activity

IV. Literature review

[source]

Gene name	SETD5
Protein name	SET domain containing 5 Histone-lysine N-methyltransferase SETD5 (EC 2.1.1.359) (EC 2.1.1.367) (SET domain-containing protein 5)
Synonyms	KIAA1757
Description	FUNCTION: Chromatin regulator required for brain development: acts as a regulator of RNA elongation rate, thereby regulating neural stem cell (NSC) proliferation and synaptic transmission. May act by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3), which is essential to allow on-time RNA elongation dynamics. Also monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. The relevance of histone methyltransferase activity is however subject to discussion. .
Accessions	ENST00000421188.1 A0A804HI68 H7C1F2 ENST00000468208.2 ENST00000415650.5 ENST00000670063.1 H0Y3R4 ENST00000665872.1 ENST00000663774.1 Q9C0A6 ENST00000488236.5 A0A804HI72 A0A804HK73 ENST00000399686.6 ENST00000402198.7 [Q9C0A6-1] A0A804HKJ9 A0A804HJ18 ENST00000478961.6 F8WD12 ENST00000406341.5 [Q9C0A6-1] F2Z2J0 A0A804HKJ6 ENST00000443339.5 ENST00000684055.1 ENST00000476740.2 ENST00000407969.5 H7C1Q2 ENST00000682536.1 ENST00000431285.5 ENST00000683262.1 E7EWN3 ENST00000684606.1 ENST00000413704.5 ENST00000683012.1 ENST00000666307.1

SETD5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review