CBFA2T2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006351Biological processDNA-templated transcription
GO_0060575Biological processintestinal epithelial cell differentiation
GO_0010977Biological processnegative regulation of neuron projection development
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0010976Biological processpositive regulation of neuron projection development
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameCBFA2T2
Protein nameProtein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85)
CBFA2/RUNX1 partner transcriptional co-repressor 2
Alternative protein CBFA2T2
SynonymsEHT
MTGR1
DKFZp313F2116
DescriptionFUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes . Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency . Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner . May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). .

AccessionsENST00000359606.3 [O43439-4]
L8EAD6
ENST00000543126.1
ENST00000344201.7 [O43439-3]
ENST00000375279.6 [O43439-1]
ENST00000346541.7 [O43439-1]
ENST00000342704.11 [O43439-5]
Q68DC6
ENST00000397800.5 [O43439-2]
O43439
ENST00000492345.5 [O43439-2]