Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 17 studies | 41% ± 19% | |
endothelial cell | 17 studies | 29% ± 14% | |
oligodendrocyte | 14 studies | 40% ± 14% | |
microglial cell | 12 studies | 31% ± 11% | |
GABAergic neuron | 11 studies | 42% ± 23% | |
glutamatergic neuron | 11 studies | 47% ± 23% | |
fibroblast | 11 studies | 28% ± 9% | |
oligodendrocyte precursor cell | 10 studies | 33% ± 13% | |
macrophage | 9 studies | 30% ± 12% | |
adipocyte | 9 studies | 28% ± 8% | |
epithelial cell | 8 studies | 33% ± 17% | |
pericyte | 7 studies | 28% ± 14% | |
smooth muscle cell | 7 studies | 24% ± 6% | |
neuron | 6 studies | 51% ± 21% | |
interneuron | 6 studies | 55% ± 17% | |
goblet cell | 6 studies | 43% ± 24% | |
amacrine cell | 5 studies | 29% ± 11% | |
ciliated cell | 5 studies | 24% ± 8% | |
retinal cone cell | 5 studies | 25% ± 6% | |
endothelial cell of lymphatic vessel | 5 studies | 26% ± 6% | |
T cell | 5 studies | 21% ± 4% | |
type I pneumocyte | 5 studies | 27% ± 7% | |
type II pneumocyte | 5 studies | 27% ± 8% | |
granule cell | 4 studies | 37% ± 11% | |
B cell | 4 studies | 20% ± 4% | |
cardiac muscle cell | 4 studies | 28% ± 2% | |
Mueller cell | 4 studies | 30% ± 6% | |
retina horizontal cell | 4 studies | 21% ± 4% | |
retinal rod cell | 4 studies | 36% ± 7% | |
monocyte | 4 studies | 27% ± 3% | |
club cell | 4 studies | 30% ± 9% | |
basal cell | 4 studies | 37% ± 23% | |
GABAergic interneuron | 3 studies | 39% ± 4% | |
glial cell | 3 studies | 23% ± 8% | |
progenitor cell | 3 studies | 55% ± 15% | |
plasma cell | 3 studies | 23% ± 5% | |
CD4-positive, alpha-beta T cell | 3 studies | 19% ± 3% | |
retinal bipolar neuron | 3 studies | 23% ± 5% | |
GABAergic amacrine cell | 3 studies | 29% ± 6% | |
glycinergic amacrine cell | 3 studies | 32% ± 5% | |
retinal ganglion cell | 3 studies | 30% ± 5% | |
hepatocyte | 3 studies | 32% ± 11% | |
connective tissue cell | 3 studies | 25% ± 6% | |
ependymal cell | 3 studies | 42% ± 16% | |
myeloid cell | 3 studies | 28% ± 5% | |
enteroendocrine cell | 3 studies | 34% ± 12% | |
alveolar macrophage | 3 studies | 31% ± 9% | |
respiratory goblet cell | 3 studies | 35% ± 13% | |
lymphocyte | 3 studies | 33% ± 5% | |
dendritic cell | 3 studies | 18% ± 1% | |
mucus secreting cell | 3 studies | 29% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2758.53 | 1445 / 1445 | 100% | 21.71 | 183 / 183 |
prostate | 100% | 5980.28 | 245 / 245 | 100% | 35.09 | 502 / 502 |
bladder | 100% | 3379.10 | 21 / 21 | 100% | 15.73 | 502 / 504 |
intestine | 100% | 4183.65 | 966 / 966 | 99% | 18.01 | 524 / 527 |
ovary | 100% | 3807.50 | 180 / 180 | 99% | 18.01 | 427 / 430 |
stomach | 100% | 2541.00 | 359 / 359 | 99% | 19.73 | 284 / 286 |
breast | 100% | 2501.08 | 459 / 459 | 99% | 18.42 | 1110 / 1118 |
skin | 100% | 3035.23 | 1808 / 1809 | 99% | 15.01 | 468 / 472 |
brain | 100% | 2799.08 | 2633 / 2642 | 99% | 14.08 | 701 / 705 |
thymus | 100% | 4066.83 | 653 / 653 | 99% | 14.79 | 599 / 605 |
lung | 100% | 2829.10 | 578 / 578 | 99% | 16.52 | 1142 / 1155 |
uterus | 100% | 3341.01 | 170 / 170 | 98% | 18.82 | 452 / 459 |
kidney | 100% | 2378.83 | 89 / 89 | 97% | 11.53 | 873 / 901 |
pancreas | 99% | 1411.29 | 326 / 328 | 96% | 11.53 | 171 / 178 |
adrenal gland | 100% | 1637.51 | 257 / 258 | 93% | 12.46 | 215 / 230 |
liver | 99% | 1262.60 | 223 / 226 | 67% | 5.89 | 271 / 406 |
adipose | 100% | 2247.71 | 1204 / 1204 | 0% | 0 | 0 / 0 |
spleen | 100% | 3175.35 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 24.14 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.85 | 1 / 1 |
blood vessel | 100% | 2536.47 | 1334 / 1335 | 0% | 0 | 0 / 0 |
muscle | 99% | 1500.42 | 798 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 1634.60 | 845 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 94% | 10.29 | 75 / 80 |
peripheral blood | 81% | 1093.02 | 752 / 929 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 76% | 6.93 | 22 / 29 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006351 | Biological process | DNA-templated transcription |
GO_0060575 | Biological process | intestinal epithelial cell differentiation |
GO_0010977 | Biological process | negative regulation of neuron projection development |
GO_0045746 | Biological process | negative regulation of Notch signaling pathway |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0010976 | Biological process | positive regulation of neuron projection development |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0005515 | Molecular function | protein binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | CBFA2T2 |
Protein name | Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85) CBFA2/RUNX1 partner transcriptional co-repressor 2 Alternative protein CBFA2T2 |
Synonyms | EHT MTGR1 DKFZp313F2116 |
Description | FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes . Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency . Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity). Can repress the expression of MMP7 in a ZBTB33-dependent manner . May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity). . |
Accessions | ENST00000359606.3 [O43439-4] L8EAD6 ENST00000543126.1 ENST00000344201.7 [O43439-3] ENST00000375279.6 [O43439-1] ENST00000346541.7 [O43439-1] ENST00000342704.11 [O43439-5] Q68DC6 ENST00000397800.5 [O43439-2] O43439 ENST00000492345.5 [O43439-2] |