SRSF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006397Biological processmRNA processing
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0033197Biological processresponse to vitamin E
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0008380Biological processRNA splicing
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005726Cellular componentperichromatin fibrils
GO_0005681Cellular componentspliceosomal complex
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0035061Cellular componentinterchromatin granule
GO_0005634Cellular componentnucleus
GO_0005080Molecular functionprotein kinase C binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0003723Molecular functionRNA binding
GO_0036002Molecular functionpre-mRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSRSF2
Protein nameSerine/arginine-rich splicing factor 2 (Protein PR264) (Splicing component, 35 kDa) (Splicing factor SC35) (SC-35) (Splicing factor, arginine/serine-rich 2)
Serine/arginine-rich splicing factor 2 (Splicing component, 35 kDa) (Splicing factor SC35) (Splicing factor, arginine/serine-rich 2)
Serine and arginine rich splicing factor 2
Serine and arginine rich splicing factor 2 transcript variant 5
SynonymsSFRS2
DescriptionFUNCTION: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway. The phosphorylated form (by SRPK2) is required for cellular apoptosis in response to cisplatin treatment. .

AccessionsA0A2I7N9Z4
ENST00000452355.7 [Q01130-1]
ENST00000585202.5 [Q01130-1]
ENST00000583836.1
ENST00000392485.2 [Q01130-1]
Q01130
ENST00000358156.7
J3KP15
J3QL05
ENST00000508921.7 [Q01130-2]
ENST00000359995.10 [Q01130-1]