TSG101 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030216Biological processkeratinocyte differentiation
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0039702Biological processviral budding via host ESCRT complex
GO_0036258Biological processmultivesicular body assembly
GO_0001558Biological processregulation of cell growth
GO_0042059Biological processnegative regulation of epidermal growth factor receptor signaling pathway
GO_0046755Biological processviral budding
GO_0016236Biological processmacroautophagy
GO_0051301Biological processcell division
GO_0043162Biological processubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_1903543Biological processpositive regulation of exosomal secretion
GO_0090148Biological processmembrane fission
GO_0043405Biological processregulation of MAP kinase activity
GO_0036211Biological processprotein modification process
GO_0008333Biological processendosome to lysosome transport
GO_0019076Biological processviral release from host cell
GO_1903774Biological processpositive regulation of viral budding via host ESCRT complex
GO_1990182Biological processexosomal secretion
GO_2000397Biological processpositive regulation of ubiquitin-dependent endocytosis
GO_0007175Biological processnegative regulation of epidermal growth factor-activated receptor activity
GO_0097352Biological processautophagosome maturation
GO_0006858Biological processextracellular transport
GO_0051726Biological processregulation of cell cycle
GO_0043328Biological processprotein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO_1903551Biological processregulation of extracellular exosome assembly
GO_0005730Cellular componentnucleolus
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0005769Cellular componentearly endosome
GO_0005813Cellular componentcentrosome
GO_0031901Cellular componentearly endosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0000813Cellular componentESCRT I complex
GO_0090543Cellular componentFlemming body
GO_0005829Cellular componentcytosol
GO_0005770Cellular componentlate endosome
GO_0005737Cellular componentcytoplasm
GO_0005771Cellular componentmultivesicular body
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0048306Molecular functioncalcium-dependent protein binding
GO_0005515Molecular functionprotein binding
GO_0046790Molecular functionvirion binding
GO_0043130Molecular functionubiquitin binding

IV. Literature review

[source]
Gene nameTSG101
Protein nameTumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)
Tumor susceptibility protein isoform 3 (Tumor susceptibility protein isoform 4)
Tumor susceptibility protein 101
Tumor susceptibility 101
Synonyms
DescriptionFUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan . It may also play a role in the extracellular release of microvesicles that differ from the exosomes . .

AccessionsJ3QKS4
J3QRU6
F5H442
ENST00000580814.1
Q99816
ENST00000584526.1
Q86SI0
L0L6B6
ENST00000251968.4 [Q99816-1]
ENST00000536719.5