SMARCA4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045582Biological processpositive regulation of T cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0045663Biological processpositive regulation of myoblast differentiation
GO_2000045Biological processregulation of G1/S transition of mitotic cell cycle
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0070316Biological processregulation of G0 to G1 transition
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0045597Biological processpositive regulation of cell differentiation
GO_0030177Biological processpositive regulation of Wnt signaling pathway
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043923Biological processpositive regulation by host of viral transcription
GO_1902895Biological processpositive regulation of miRNA transcription
GO_0060766Biological processnegative regulation of androgen receptor signaling pathway
GO_2000819Biological processregulation of nucleotide-excision repair
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0045596Biological processnegative regulation of cell differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0001188Biological processRNA polymerase I preinitiation complex assembly
GO_1901838Biological processpositive regulation of transcription of nucleolar large rRNA by RNA polymerase I
GO_0007399Biological processnervous system development
GO_0006337Biological processnucleosome disassembly
GO_2000781Biological processpositive regulation of double-strand break repair
GO_1902661Biological processpositive regulation of glucose mediated signaling pathway
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0003407Biological processneural retina development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0030308Biological processnegative regulation of cell growth
GO_0140288Cellular componentGBAF complex
GO_0005730Cellular componentnucleolus
GO_0005615Cellular componentextracellular space
GO_0071565Cellular componentnBAF complex
GO_0016020Cellular componentmembrane
GO_0071564Cellular componentnpBAF complex
GO_0000776Cellular componentkinetochore
GO_0032991Cellular componentprotein-containing complex
GO_0016514Cellular componentSWI/SNF complex
GO_0005654Cellular componentnucleoplasm
GO_0001650Cellular componentfibrillar center
GO_0016363Cellular componentnuclear matrix
GO_0016586Cellular componentRSC-type complex
GO_0140092Cellular componentbBAF complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0008134Molecular functiontranscription factor binding
GO_0003677Molecular functionDNA binding
GO_0004386Molecular functionhelicase activity
GO_0070182Molecular functionDNA polymerase binding
GO_0030957Molecular functionTat protein binding
GO_0001221Molecular functiontranscription coregulator binding
GO_0031492Molecular functionnucleosomal DNA binding
GO_0070577Molecular functionlysine-acetylated histone binding
GO_0016787Molecular functionhydrolase activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0002039Molecular functionp53 binding
GO_0005524Molecular functionATP binding
GO_0001164Molecular functionRNA polymerase I core promoter sequence-specific DNA binding
GO_0003723Molecular functionRNA binding
GO_0050681Molecular functionnuclear androgen receptor binding
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSMARCA4
Protein nameSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCA4 isoform 2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4)
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (cDNA FLJ77531, highly similar to Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), mRNA)
SMARCA4 protein
Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4)
SynonymsBRG1
SNF2B
hCG_29955
SNF2L4
BAF190A
DescriptionFUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). .

AccessionsP51532
A0A2R8Y6N0
A0A2R8YF38
ENST00000704345.1
ENST00000642726.1
ENST00000711079.1
ENST00000591545.6
A0A2R8Y6V2
A0A2R8Y7Y7
ENST00000592158.2
ENST00000643296.1 [P51532-4]
ENST00000646513.1
ENST00000344626.10 [P51532-1]
ENST00000429416.8 [P51532-1]
ENST00000642350.1
A0A994J4Z2
A5D6X0
A0A2R8Y7S2
ENST00000644963.1
A0A994J6Y9
ENST00000590574.6 [P51532-2]
ENST00000646593.1
ENST00000645648.1
A0A2R8Y5K3
A7E2E1
Q9HBD4
A0A2R8YFV8
A0A2R8Y523
A0A2R8Y4R6
ENST00000643208.1
A0A2R8YF80
B9EGQ8
ENST00000642508.1
ENST00000644327.1
A0A2R8Y4C5
ENST00000644065.1
A0A2R8Y440
A0A2R8YFK5
A0A2R8Y583
ENST00000643534.1
A0A2R8Y866
ENST00000644290.1
ENST00000645236.1
ENST00000646183.1
ENST00000645387.1
A0A2R8YCY3
ENST00000646236.1
K7EP28
ENST00000642628.1
ENST00000643857.1
A0A2R8Y526
ENST00000644737.1 [P51532-4]
A0A2R8Y7F3
A0A2R8Y7R0
A0A2R8YF58
ENST00000541122.6 [P51532-4]
ENST00000646484.1 [P51532-2]
ENST00000646510.1 [P51532-2]
ENST00000643549.1
ENST00000589677.5 [P51532-3]
ENST00000538456.4
ENST00000645061.1
K7EQF0
ENST00000586985.2
ENST00000704344.1
ENST00000643995.1
A0A2R8YGP5
ENST00000647230.1 [P51532-2]
ENST00000646693.2
ENST00000444061.8 [P51532-5]
A0A2R8Y4P4
ENST00000644760.1
A0A2R8YGG3
ENST00000647268.1
A0A2R8YG32
ENST00000645460.1 [P51532-5]
ENST00000646746.1
A0A2R8YDA1