Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 17 studies | 27% ± 13% | |
ciliated cell | 13 studies | 31% ± 11% | |
oligodendrocyte precursor cell | 12 studies | 27% ± 9% | |
fibroblast | 11 studies | 19% ± 2% | |
type I pneumocyte | 9 studies | 20% ± 5% | |
pericyte | 9 studies | 25% ± 11% | |
astrocyte | 9 studies | 27% ± 9% | |
glutamatergic neuron | 8 studies | 41% ± 21% | |
neuron | 8 studies | 48% ± 13% | |
epithelial cell | 8 studies | 42% ± 17% | |
B cell | 7 studies | 27% ± 5% | |
basal cell | 7 studies | 30% ± 11% | |
smooth muscle cell | 7 studies | 18% ± 3% | |
interneuron | 7 studies | 39% ± 18% | |
GABAergic neuron | 7 studies | 41% ± 17% | |
oligodendrocyte | 7 studies | 24% ± 6% | |
myofibroblast cell | 6 studies | 20% ± 5% | |
abnormal cell | 6 studies | 25% ± 8% | |
macrophage | 6 studies | 27% ± 8% | |
precursor B cell | 6 studies | 40% ± 13% | |
type II pneumocyte | 6 studies | 22% ± 5% | |
CD4-positive, alpha-beta T cell | 5 studies | 19% ± 3% | |
progenitor cell | 5 studies | 24% ± 8% | |
connective tissue cell | 5 studies | 27% ± 8% | |
amacrine cell | 5 studies | 31% ± 12% | |
pro-B cell | 5 studies | 46% ± 7% | |
myeloid cell | 5 studies | 21% ± 4% | |
club cell | 5 studies | 29% ± 11% | |
retina horizontal cell | 5 studies | 26% ± 11% | |
goblet cell | 5 studies | 27% ± 11% | |
respiratory goblet cell | 4 studies | 28% ± 9% | |
hematopoietic precursor cell | 4 studies | 29% ± 7% | |
T cell | 4 studies | 22% ± 7% | |
microglial cell | 4 studies | 28% ± 8% | |
retinal ganglion cell | 4 studies | 42% ± 21% | |
natural killer cell | 4 studies | 18% ± 3% | |
enteroendocrine cell | 4 studies | 24% ± 8% | |
ionocyte | 3 studies | 30% ± 2% | |
secretory cell | 3 studies | 26% ± 6% | |
non-classical monocyte | 3 studies | 27% ± 10% | |
neural crest cell | 3 studies | 33% ± 1% | |
retinal bipolar neuron | 3 studies | 25% ± 7% | |
GABAergic interneuron | 3 studies | 29% ± 14% | |
granule cell | 3 studies | 27% ± 3% | |
squamous epithelial cell | 3 studies | 45% ± 22% | |
brush cell | 3 studies | 32% ± 7% | |
immature B cell | 3 studies | 35% ± 16% | |
adipocyte | 3 studies | 17% ± 2% | |
lymphocyte | 3 studies | 22% ± 2% | |
GABAergic amacrine cell | 3 studies | 25% ± 6% | |
germinal center B cell | 3 studies | 21% ± 3% | |
CD8-positive, alpha-beta T cell | 3 studies | 21% ± 3% | |
hematopoietic stem cell | 3 studies | 23% ± 7% | |
intestinal crypt stem cell | 3 studies | 16% ± 1% | |
endothelial cell of lymphatic vessel | 3 studies | 22% ± 3% | |
monocyte | 3 studies | 16% ± 1% | |
transit amplifying cell | 3 studies | 30% ± 10% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 6709.16 | 245 / 245 | 100% | 41.45 | 502 / 502 |
skin | 100% | 9125.11 | 1809 / 1809 | 100% | 51.61 | 472 / 472 |
stomach | 100% | 4533.85 | 359 / 359 | 100% | 39.25 | 286 / 286 |
esophagus | 100% | 7004.47 | 1444 / 1445 | 100% | 44.18 | 183 / 183 |
thymus | 100% | 7393.60 | 653 / 653 | 100% | 42.13 | 604 / 605 |
breast | 100% | 5761.11 | 459 / 459 | 100% | 43.56 | 1115 / 1118 |
intestine | 100% | 5569.76 | 966 / 966 | 100% | 40.75 | 525 / 527 |
uterus | 100% | 5824.95 | 170 / 170 | 100% | 46.31 | 457 / 459 |
brain | 100% | 7037.06 | 2637 / 2642 | 99% | 45.62 | 700 / 705 |
bladder | 100% | 5768.76 | 21 / 21 | 99% | 42.56 | 497 / 504 |
ovary | 100% | 5540.49 | 180 / 180 | 99% | 46.08 | 424 / 430 |
kidney | 100% | 6855.17 | 89 / 89 | 98% | 23.42 | 882 / 901 |
adrenal gland | 100% | 6114.53 | 258 / 258 | 98% | 28.50 | 225 / 230 |
lung | 100% | 6396.29 | 578 / 578 | 98% | 38.21 | 1127 / 1155 |
pancreas | 100% | 3344.24 | 327 / 328 | 98% | 29.14 | 174 / 178 |
liver | 96% | 2250.62 | 217 / 226 | 89% | 16.68 | 360 / 406 |
eye | 0% | 0 | 0 / 0 | 100% | 49.17 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 34.30 | 29 / 29 |
spleen | 100% | 5909.29 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 48.16 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 42.21 | 1 / 1 |
adipose | 100% | 4746.95 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4601.49 | 1333 / 1335 | 0% | 0 | 0 / 0 |
muscle | 100% | 4715.67 | 800 / 803 | 0% | 0 | 0 / 0 |
heart | 96% | 3396.26 | 828 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 83% | 4048.07 | 768 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0030071 | Biological process | regulation of mitotic metaphase/anaphase transition |
GO_0051091 | Biological process | positive regulation of DNA-binding transcription factor activity |
GO_0045582 | Biological process | positive regulation of T cell differentiation |
GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
GO_0045663 | Biological process | positive regulation of myoblast differentiation |
GO_2000045 | Biological process | regulation of G1/S transition of mitotic cell cycle |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0006338 | Biological process | chromatin remodeling |
GO_0070316 | Biological process | regulation of G0 to G1 transition |
GO_1902459 | Biological process | positive regulation of stem cell population maintenance |
GO_0045597 | Biological process | positive regulation of cell differentiation |
GO_0030177 | Biological process | positive regulation of Wnt signaling pathway |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0043923 | Biological process | positive regulation by host of viral transcription |
GO_1902895 | Biological process | positive regulation of miRNA transcription |
GO_0060766 | Biological process | negative regulation of androgen receptor signaling pathway |
GO_2000819 | Biological process | regulation of nucleotide-excision repair |
GO_0120162 | Biological process | positive regulation of cold-induced thermogenesis |
GO_0045596 | Biological process | negative regulation of cell differentiation |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0001188 | Biological process | RNA polymerase I preinitiation complex assembly |
GO_1901838 | Biological process | positive regulation of transcription of nucleolar large rRNA by RNA polymerase I |
GO_0007399 | Biological process | nervous system development |
GO_0006337 | Biological process | nucleosome disassembly |
GO_2000781 | Biological process | positive regulation of double-strand break repair |
GO_1902661 | Biological process | positive regulation of glucose mediated signaling pathway |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0045815 | Biological process | transcription initiation-coupled chromatin remodeling |
GO_0003407 | Biological process | neural retina development |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0030308 | Biological process | negative regulation of cell growth |
GO_0140288 | Cellular component | GBAF complex |
GO_0005730 | Cellular component | nucleolus |
GO_0005615 | Cellular component | extracellular space |
GO_0071565 | Cellular component | nBAF complex |
GO_0016020 | Cellular component | membrane |
GO_0071564 | Cellular component | npBAF complex |
GO_0000776 | Cellular component | kinetochore |
GO_0032991 | Cellular component | protein-containing complex |
GO_0016514 | Cellular component | SWI/SNF complex |
GO_0005654 | Cellular component | nucleoplasm |
GO_0001650 | Cellular component | fibrillar center |
GO_0016363 | Cellular component | nuclear matrix |
GO_0016586 | Cellular component | RSC-type complex |
GO_0140092 | Cellular component | bBAF complex |
GO_0000785 | Cellular component | chromatin |
GO_0005634 | Cellular component | nucleus |
GO_0008134 | Molecular function | transcription factor binding |
GO_0003677 | Molecular function | DNA binding |
GO_0004386 | Molecular function | helicase activity |
GO_0070182 | Molecular function | DNA polymerase binding |
GO_0030957 | Molecular function | Tat protein binding |
GO_0001221 | Molecular function | transcription coregulator binding |
GO_0031492 | Molecular function | nucleosomal DNA binding |
GO_0070577 | Molecular function | lysine-acetylated histone binding |
GO_0016787 | Molecular function | hydrolase activity |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0002039 | Molecular function | p53 binding |
GO_0005524 | Molecular function | ATP binding |
GO_0001164 | Molecular function | RNA polymerase I core promoter sequence-specific DNA binding |
GO_0003723 | Molecular function | RNA binding |
GO_0050681 | Molecular function | nuclear androgen receptor binding |
GO_0140658 | Molecular function | ATP-dependent chromatin remodeler activity |
GO_0008094 | Molecular function | ATP-dependent activity, acting on DNA |
GO_0003713 | Molecular function | transcription coactivator activity |
GO_0005515 | Molecular function | protein binding |
Gene name | SMARCA4 |
Protein name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 SMARCA4 isoform 2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4) SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (cDNA FLJ77531, highly similar to Homo sapiens SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4), mRNA) SMARCA4 protein Transcription activator BRG1 (EC 3.6.4.-) (ATP-dependent helicase SMARCA4) (BRG1-associated factor 190A) (BAF190A) (Mitotic growth and transcription activator) (Protein BRG-1) (Protein brahma homolog 1) (SNF2-beta) (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4) |
Synonyms | BRG1 SNF2B hCG_29955 SNF2L4 BAF190A |
Description | FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor complex and the recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by SMARCA4-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves the release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development, a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals, while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues (By similarity). Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Binds via DLX1 to enhancers located in the intergenic region between DLX5 and DLX6 and this binding is stabilized by the long non-coding RNA (lncRNA) Evf2 (By similarity). Binds to RNA in a promiscuous manner (By similarity). Binding to RNAs including lncRNA Evf2 leads to inhibition of SMARCA4 ATPase and chromatin remodeling activities (By similarity). In brown adipose tissue, involved in the regulation of thermogenic genes expression (By similarity). . |
Accessions | P51532 A0A2R8Y6N0 A0A2R8YF38 ENST00000704345.1 ENST00000642726.1 ENST00000711079.1 ENST00000591545.6 A0A2R8Y6V2 A0A2R8Y7Y7 ENST00000592158.2 ENST00000643296.1 [P51532-4] ENST00000646513.1 ENST00000344626.10 [P51532-1] ENST00000429416.8 [P51532-1] ENST00000642350.1 A0A994J4Z2 A5D6X0 A0A2R8Y7S2 ENST00000644963.1 A0A994J6Y9 ENST00000590574.6 [P51532-2] ENST00000646593.1 ENST00000645648.1 A0A2R8Y5K3 A7E2E1 Q9HBD4 A0A2R8YFV8 A0A2R8Y523 A0A2R8Y4R6 ENST00000643208.1 A0A2R8YF80 B9EGQ8 ENST00000642508.1 ENST00000644327.1 A0A2R8Y4C5 ENST00000644065.1 A0A2R8Y440 A0A2R8YFK5 A0A2R8Y583 ENST00000643534.1 A0A2R8Y866 ENST00000644290.1 ENST00000645236.1 ENST00000646183.1 ENST00000645387.1 A0A2R8YCY3 ENST00000646236.1 K7EP28 ENST00000642628.1 ENST00000643857.1 A0A2R8Y526 ENST00000644737.1 [P51532-4] A0A2R8Y7F3 A0A2R8Y7R0 A0A2R8YF58 ENST00000541122.6 [P51532-4] ENST00000646484.1 [P51532-2] ENST00000646510.1 [P51532-2] ENST00000643549.1 ENST00000589677.5 [P51532-3] ENST00000538456.4 ENST00000645061.1 K7EQF0 ENST00000586985.2 ENST00000704344.1 ENST00000643995.1 A0A2R8YGP5 ENST00000647230.1 [P51532-2] ENST00000646693.2 ENST00000444061.8 [P51532-5] A0A2R8Y4P4 ENST00000644760.1 A0A2R8YGG3 ENST00000647268.1 A0A2R8YG32 ENST00000645460.1 [P51532-5] ENST00000646746.1 A0A2R8YDA1 |