ZNF451 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0060633Biological processnegative regulation of transcription initiation by RNA polymerase II
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0016605Cellular componentPML body
GO_0005634Cellular componentnucleus
GO_0061665Molecular functionSUMO ligase activity
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNF451
Protein nameZNF451 protein
E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451)
Zinc finger protein 451
SynonymsKIAA0576
KIAA1702
COASTER
DescriptionFUNCTION: E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins . Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 . Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' . Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' . Plays a role in regulating the transcription of AR targets . .

AccessionsENST00000491832.6
ENST00000508603.5
ENST00000504603.1
ENST00000370711.9
D6RIA1
ENST00000502749.1
D6REC5
Q9Y4E5
D6RB93
Q4KMR5
Q5VVF0
ENST00000357489.7 [Q9Y4E5-2]
D6RAS1
ENST00000370708.8 [Q9Y4E5-4]
ENST00000370702.5
D6RAV4
ENST00000370710.10
ENST00000370706.9 [Q9Y4E5-1]
Q5VVE8
E9PH99
ENST00000515290.5
ENST00000510483.5