Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 20 studies | 30% ± 14% | |
oligodendrocyte | 15 studies | 38% ± 16% | |
glutamatergic neuron | 10 studies | 42% ± 25% | |
fibroblast | 10 studies | 24% ± 10% | |
astrocyte | 10 studies | 34% ± 15% | |
microglial cell | 9 studies | 26% ± 9% | |
oligodendrocyte precursor cell | 9 studies | 34% ± 16% | |
GABAergic neuron | 8 studies | 42% ± 21% | |
adipocyte | 8 studies | 26% ± 7% | |
B cell | 7 studies | 24% ± 5% | |
neuron | 7 studies | 34% ± 19% | |
epithelial cell | 7 studies | 33% ± 17% | |
natural killer cell | 6 studies | 23% ± 9% | |
endothelial cell of lymphatic vessel | 6 studies | 24% ± 9% | |
interneuron | 6 studies | 41% ± 24% | |
type I pneumocyte | 6 studies | 23% ± 7% | |
macrophage | 6 studies | 30% ± 9% | |
smooth muscle cell | 6 studies | 21% ± 4% | |
T cell | 5 studies | 19% ± 2% | |
naive B cell | 5 studies | 16% ± 0% | |
pericyte | 5 studies | 25% ± 10% | |
naive thymus-derived CD4-positive, alpha-beta T cell | 4 studies | 17% ± 3% | |
granule cell | 4 studies | 23% ± 6% | |
myeloid cell | 4 studies | 20% ± 3% | |
amacrine cell | 4 studies | 22% ± 7% | |
retina horizontal cell | 4 studies | 22% ± 11% | |
cardiac muscle cell | 4 studies | 19% ± 1% | |
lymphocyte | 4 studies | 25% ± 9% | |
regulatory T cell | 4 studies | 21% ± 8% | |
dendritic cell | 4 studies | 29% ± 12% | |
erythrocyte | 4 studies | 51% ± 18% | |
CD4-positive, alpha-beta T cell | 3 studies | 22% ± 5% | |
GABAergic interneuron | 3 studies | 27% ± 2% | |
retinal bipolar neuron | 3 studies | 17% ± 1% | |
retinal cone cell | 3 studies | 25% ± 5% | |
mesothelial cell | 3 studies | 22% ± 5% | |
ciliated cell | 3 studies | 30% ± 5% | |
CD8-positive, alpha-beta T cell | 3 studies | 21% ± 4% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 19% ± 3% | |
hepatocyte | 3 studies | 36% ± 19% | |
leukocyte | 3 studies | 20% ± 3% | |
club cell | 3 studies | 22% ± 7% | |
monocyte | 3 studies | 21% ± 2% | |
type II pneumocyte | 3 studies | 19% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 2088.22 | 1445 / 1445 | 100% | 9.98 | 183 / 183 |
lung | 100% | 2762.80 | 578 / 578 | 100% | 7.67 | 1155 / 1155 |
brain | 100% | 2223.80 | 2639 / 2642 | 100% | 7.50 | 704 / 705 |
breast | 100% | 2529.45 | 459 / 459 | 100% | 8.59 | 1114 / 1118 |
prostate | 100% | 2710.98 | 245 / 245 | 100% | 8.15 | 500 / 502 |
thymus | 100% | 2954.46 | 653 / 653 | 99% | 7.11 | 598 / 605 |
uterus | 100% | 2749.25 | 170 / 170 | 99% | 6.78 | 453 / 459 |
bladder | 100% | 2255.81 | 21 / 21 | 99% | 6.74 | 497 / 504 |
pancreas | 100% | 1276.50 | 328 / 328 | 98% | 5.51 | 175 / 178 |
adrenal gland | 100% | 3436.44 | 258 / 258 | 97% | 6.98 | 223 / 230 |
stomach | 100% | 2011.70 | 359 / 359 | 97% | 6.77 | 277 / 286 |
intestine | 100% | 2437.75 | 966 / 966 | 97% | 5.92 | 510 / 527 |
ovary | 100% | 2653.79 | 180 / 180 | 95% | 4.99 | 408 / 430 |
kidney | 100% | 1550.76 | 89 / 89 | 93% | 5.28 | 842 / 901 |
skin | 100% | 2218.23 | 1808 / 1809 | 90% | 6.59 | 426 / 472 |
liver | 100% | 1422.01 | 226 / 226 | 85% | 3.60 | 347 / 406 |
adipose | 100% | 2578.50 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 2223.65 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 5.74 | 29 / 29 |
spleen | 100% | 3035.85 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 6.51 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 3.73 | 1 / 1 |
muscle | 99% | 1219.53 | 798 / 803 | 0% | 0 | 0 / 0 |
heart | 98% | 1328.93 | 844 / 861 | 0% | 0 | 0 / 0 |
peripheral blood | 75% | 1241.56 | 701 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 68% | 3.55 | 54 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0016925 | Biological process | protein sumoylation |
GO_0060633 | Biological process | negative regulation of transcription initiation by RNA polymerase II |
GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
GO_0016605 | Cellular component | PML body |
GO_0005634 | Cellular component | nucleus |
GO_0061665 | Molecular function | SUMO ligase activity |
GO_0140416 | Molecular function | transcription regulator inhibitor activity |
GO_0003714 | Molecular function | transcription corepressor activity |
GO_0005515 | Molecular function | protein binding |
GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
GO_0043565 | Molecular function | sequence-specific DNA binding |
GO_0046872 | Molecular function | metal ion binding |
Gene name | ZNF451 |
Protein name | ZNF451 protein E3 SUMO-protein ligase ZNF451 (EC 2.3.2.-) (Coactivator for steroid receptors) (E3 SUMO-protein transferase ZNF451) (Zinc finger protein 451) Zinc finger protein 451 |
Synonyms | KIAA0576 KIAA1702 COASTER |
Description | FUNCTION: E3 SUMO-protein ligase; has a preference for SUMO2 and SUMO3 and facilitates UBE2I/UBC9-mediated sumoylation of target proteins . Plays a role in protein SUMO2 modification in response to stress caused by DNA damage and by proteasome inhibitors (in vitro). Required for MCM4 sumoylation (By similarity). Has no activity with SUMO1 . Preferentially transfers an additional SUMO2 chain onto the SUMO2 consensus site 'Lys-11' . Negatively regulates transcriptional activation mediated by the SMAD4 complex in response to TGF-beta signaling. Inhibits EP300-mediated acetylation of histone H3 at 'Lys-9' . Plays a role in regulating the transcription of AR targets . . |
Accessions | ENST00000491832.6 ENST00000508603.5 ENST00000504603.1 ENST00000370711.9 D6RIA1 ENST00000502749.1 D6REC5 Q9Y4E5 D6RB93 Q4KMR5 Q5VVF0 ENST00000357489.7 [Q9Y4E5-2] D6RAS1 ENST00000370708.8 [Q9Y4E5-4] ENST00000370702.5 D6RAV4 ENST00000370710.10 ENST00000370706.9 [Q9Y4E5-1] Q5VVE8 E9PH99 ENST00000515290.5 ENST00000510483.5 |