ZNF541 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZNF541 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZNF541 at tissue level.

III. Associated gene sets

GO_0007283Biological processspermatogenesis
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030154Biological processcell differentiation
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0007140Biological processmale meiotic nuclear division
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000118Cellular componenthistone deacetylase complex
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNF541
Protein nameZinc finger protein 541
Synonyms
DescriptionFUNCTION: Transcription regulator which is essential for male fertility and for the completion of meiotic prophase in spermatocytes. Regulates progression of the pachytene stage of meiotic prophase by activating the expression of genes involved in meiosis during spermatogenesis. Maintains the repression of pre-pachytene transcriptional programs, including meiotic double-strand breaks (DSB) formation genes in pachytene spermatocytes and suppresses aberrant DSB formation after mid-pachytene, thus ensuring meiosis progression. .

AccessionsENST00000391901.8 [Q9H0D2-3]
ENST00000263351.9
ENST00000595558.1
M0R167
H7BXG6
Q9H0D2