TRIM22 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000209Biological processprotein polyubiquitination
GO_0051091Biological processpositive regulation of DNA-binding transcription factor activity
GO_0045087Biological processinnate immune response
GO_0009615Biological processresponse to virus
GO_0051607Biological processdefense response to virus
GO_0032880Biological processregulation of protein localization
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0006955Biological processimmune response
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0010508Biological processpositive regulation of autophagy
GO_0006355Biological processregulation of DNA-templated transcription
GO_0070534Biological processprotein K63-linked ubiquitination
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0046596Biological processregulation of viral entry into host cell
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0015030Cellular componentCajal body
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0019901Molecular functionprotein kinase binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0042802Molecular functionidentical protein binding
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0008270Molecular functionzinc ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIM22
Protein nameTripartite binding motif 22
Tripartite motif containing 22
E3 ubiquitin-protein ligase TRIM22 (EC 2.3.2.27) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (RING-type E3 ubiquitin transferase TRIM22) (Staf-50) (Tripartite motif-containing protein 22)
Tripartite motif-containing 22
SynonymsRNF94
hCG_1788111
STAF50
DescriptionFUNCTION: Interferon-induced E3 ubiquitin ligase that plays important roles in innate and adaptive immunity . Restricts the replication of many viruses including HIV-1, encephalomyocarditis virus (EMCV), hepatitis B virus (HBV), hepatitis C virus (HCV) or Zika virus (ZIKV) . Mechanistically, negatively regulates HCV replication by promoting ubiquitination and subsequent degradation of viral NS5A . Acts also by promoting the degradation of Zika virus NS1 and NS3 proteins through proteasomal degradation . Acts as a suppressor of basal HIV-1 LTR-driven transcription by preventing Sp1 binding to the HIV-1 promoter . Plays also a role in antiviral immunity by co-regulating together with NT5C2 the RIGI/NF-kappa-B pathway by promoting 'Lys-63'-linked ubiquitination of RIGI, while NT5C2 is responsible for 'Lys-48'-linked ubiquitination of RIGI . Participates in adaptive immunity by suppressing the amount of MHC class II protein in a negative feedback manner in order to limit the extent of MHC class II induction . .

AccessionsENST00000414641.5
H7C262
A0A8V8TP25
H7C2K0
ENST00000379965.8 [Q8IYM9-1]
ENST00000699053.1
C9J060
H7BZD3
Q8IYM9
ENST00000425490.5
ENST00000429063.5
ENST00000450670.5
A0A8V8TN39
D3DQT0
H7C376
A0A348GSH8
ENST00000414897.5
C9JWC5
Q4A1P5
ENST00000454828.6
ENST00000699057.1
ENST00000444844.1
C9JIU5