TOB1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
CD4-positive, alpha-beta T cell	23 studies	28% ± 8%	Explore
epithelial cell	18 studies	37% ± 20%	Explore
CD8-positive, alpha-beta T cell	18 studies	26% ± 11%	Explore
smooth muscle cell	17 studies	26% ± 11%	Explore
T cell	15 studies	29% ± 10%	Explore
ciliated cell	15 studies	33% ± 17%	Explore
conventional dendritic cell	15 studies	30% ± 16%	Explore
basal cell	15 studies	31% ± 15%	Explore
pericyte	13 studies	29% ± 11%	Explore
regulatory T cell	13 studies	22% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	30% ± 12%	Explore
fibroblast	12 studies	30% ± 16%	Explore
mucosal invariant T cell	11 studies	31% ± 8%	Explore
goblet cell	10 studies	28% ± 11%	Explore
secretory cell	9 studies	26% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	38% ± 16%	Explore
mature NK T cell	9 studies	27% ± 11%	Explore
astrocyte	9 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	27% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	32% ± 14%	Explore
club cell	7 studies	26% ± 10%	Explore
endothelial cell	7 studies	26% ± 7%	Explore
dendritic cell	6 studies	32% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	25% ± 6%	Explore
gamma-delta T cell	6 studies	25% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	6 studies	33% ± 16%	Explore
type I pneumocyte	5 studies	28% ± 6%	Explore
non-classical monocyte	5 studies	33% ± 14%	Explore
classical monocyte	5 studies	26% ± 12%	Explore
mesothelial cell	5 studies	33% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	33% ± 16%	Explore
monocyte	4 studies	24% ± 4%	Explore
type II pneumocyte	4 studies	23% ± 7%	Explore
duct epithelial cell	4 studies	27% ± 6%	Explore
respiratory goblet cell	4 studies	33% ± 17%	Explore
squamous epithelial cell	4 studies	44% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	20% ± 1%	Explore
myofibroblast cell	4 studies	26% ± 8%	Explore
connective tissue cell	4 studies	29% ± 5%	Explore
myeloid cell	4 studies	29% ± 12%	Explore
retinal pigment epithelial cell	4 studies	45% ± 15%	Explore
Mueller cell	4 studies	36% ± 5%	Explore
intestinal crypt stem cell	4 studies	24% ± 6%	Explore
natural killer cell	3 studies	20% ± 3%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	28% ± 8%	Explore
leukocyte	3 studies	23% ± 3%	Explore
retinal bipolar neuron	3 studies	46% ± 14%	Explore
abnormal cell	3 studies	30% ± 9%	Explore
brush cell	3 studies	27% ± 9%	Explore
progenitor cell	3 studies	21% ± 4%	Explore
retinal cone cell	3 studies	35% ± 11%	Explore
mucus secreting cell	3 studies	26% ± 1%	Explore
serous secreting cell	3 studies	34% ± 5%	Explore
rod bipolar cell	3 studies	46% ± 3%	Explore
CD4-positive helper T cell	3 studies	25% ± 3%	Explore
GABAergic neuron	3 studies	20% ± 1%	Explore
glutamatergic neuron	3 studies	22% ± 3%	Explore
enterocyte	3 studies	20% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	23% ± 2%	Explore
T follicular helper cell	3 studies	27% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	18% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	28% ± 1%	Explore
double negative thymocyte	3 studies	24% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	39% ± 16%	Explore
myoepithelial cell	3 studies	38% ± 11%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	9 studies	26% ± 9%	Explore
lung	8 studies	25% ± 8%	Explore
eye	7 studies	31% ± 10%	Explore
brain	5 studies	19% ± 3%	Explore
intestine	5 studies	22% ± 4%	Explore
kidney	3 studies	20% ± 3%	Explore
uterus	3 studies	33% ± 6%	Explore
breast	3 studies	26% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
stomach	99%	6634.81	356 / 359	99%	132.16	284 / 286
prostate	99%	6684.49	242 / 245	100%	200.48	500 / 502
pancreas	100%	6429.13	328 / 328	98%	151.01	174 / 178
breast	99%	7459.36	454 / 459	99%	263.52	1105 / 1118
esophagus	99%	4563.64	1427 / 1445	98%	111.17	180 / 183
intestine	98%	3465.58	945 / 966	99%	135.46	523 / 527
bladder	100%	7938.33	21 / 21	96%	149.38	482 / 504
liver	99%	8771.72	224 / 226	96%	148.63	391 / 406
adrenal gland	100%	10497.19	257 / 258	94%	110.11	216 / 230
kidney	96%	3224.72	85 / 89	96%	109.34	868 / 901
ovary	91%	4608.65	164 / 180	99%	82.29	425 / 430
thymus	95%	3151.81	618 / 653	93%	82.52	560 / 605
brain	90%	2252.01	2365 / 2642	96%	53.47	676 / 705
lung	87%	2396.39	500 / 578	97%	90.99	1118 / 1155
skin	98%	9574.20	1780 / 1809	81%	50.99	383 / 472
uterus	82%	2104.71	140 / 170	95%	105.31	436 / 459
ureter	0%	0	0 / 0	100%	80.84	1 / 1
blood vessel	98%	8630.73	1313 / 1335	0%	0	0 / 0
muscle	98%	5300.67	785 / 803	0%	0	0 / 0
adipose	97%	3699.84	1170 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	91%	71.26	41 / 45
heart	85%	2148.12	733 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	75%	44.05	60 / 80
spleen	71%	1316.21	170 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	59%	21.05	17 / 29
peripheral blood	49%	1102.73	457 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1900153	Biological process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0010468	Biological process	regulation of gene expression
GO_0008285	Biological process	negative regulation of cell population proliferation
GO_0060213	Biological process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0030514	Biological process	negative regulation of BMP signaling pathway
GO_0045892	Biological process	negative regulation of DNA-templated transcription
GO_0045668	Biological process	negative regulation of osteoblast differentiation
GO_0017148	Biological process	negative regulation of translation
GO_0060390	Biological process	regulation of SMAD protein signal transduction
GO_0060212	Biological process	negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0030014	Cellular component	CCR4-NOT complex
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0046332	Molecular function	SMAD binding
GO_0003714	Molecular function	transcription corepressor activity
GO_0005515	Molecular function	protein binding
GO_0030971	Molecular function	receptor tyrosine kinase binding

IV. Literature review

[source]

Gene name	TOB1
Protein name	Protein Tob1 (Transducer of erbB-2 1)
Synonyms	TROB1 TOB
Description	FUNCTION: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex . Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay . .
Accessions	ENST00000268957.3 ENST00000499247.3 P50616

TOB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review