DNMT3B report

I. Expression across cell types

Insufficient scRNA-seq data for expression of DNMT3B at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of DNMT3B at tissue level.

III. Associated gene sets

GO_0010628Biological processpositive regulation of gene expression
GO_0032259Biological processmethylation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_1902494Cellular componentcatalytic complex
GO_0005634Cellular componentnucleus
GO_0009008Molecular functionDNA-methyltransferase activity
GO_0003677Molecular functionDNA binding
GO_0051718Molecular functionDNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
GO_0003714Molecular functiontranscription corepressor activity
GO_0005515Molecular functionprotein binding
GO_0003886Molecular functionDNA (cytosine-5-)-methyltransferase activity
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameDNMT3B
Protein nameDNA cytosine-5--methyltransferase 3 beta transcript variant 9 (EC 2.1.1.37) (DNA methyltransferase 3 beta)
DNA methyltransferase 3 beta transcript variant 1
DNA (cytosine-5-)-methyltransferase (EC 2.1.1.37)
DNA methyltransferase 3 beta
DNA methyltransferase 3 beta (cDNA FLJ52873, highly similar to DNA (cytosine-5)-methyltransferase 3B)
DNA (cytosine-5)-methyltransferase 3B (Dnmt3b) (EC 2.1.1.37) (DNA methyltransferase HsaIIIB) (DNA MTase HsaIIIB) (M.HsaIIIB)
DNA methyltransferase
Synonyms
DescriptionFUNCTION: Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Functions as a transcriptional corepressor by associating with ZHX1. Required for DUX4 silencing in somatic cells . .

AccessionsENST00000696236.1
B4DSJ7
A0A8Q3SIL8
A0A8Q3SIJ5
ENST00000696232.1
ENST00000348286.6 [Q9UBC3-3]
Q9UBC3
ENST00000696235.1
ENST00000353855.6 [Q9UBC3-2]
ENST00000696238.1
ENST00000696231.1
ENST00000456297.6 [Q9UBC3-7]
ENST00000696239.1
ENST00000443239.7 [Q9UBC3-8]
A0A8Q3SIG2
A0A2Z2CIT2
ENST00000201963.3 [Q9UBC3-6]
A0A8G0D2L9
Q2PJS8
ENST00000328111.6 [Q9UBC3-1]
ENST00000696233.1